Vitamin B-12 deficiency is a common problem encountered in developing countries of the world. In Europe and North America it is frequently encountered in the elderly and in people whose diets are compromised such as alcoholics. Recent data has shown that cobalamin deficiency may occur in 5% to 40% of the general population. The prevalence as stated earlier is higher in the elderly and in nursin...

A progress report stated that perfused hearts could be maintained over a longer period if vitamin B complex were added to the perfusate. The present study comprises analyses of four of the B vitamins in muscle of control hearts, of hearts perfused with oxygenated Locke's solution and of hearts perfused with the same solution plus dihydropaveril. Statistically significant amounts of B vitamins d...

MANY types of micro-organisms have been tested by various workers for their ability to synthesize "vitamin B" (=complex). In such studies the organisms were grown in various nutrient media and the " vitamin B " was detected by its growth-promoting action or by curative tests on experimental animals such as the rat, the mouse or the pigeon. Thus "vitamin B " has been reported to have been produc...

Since the demonstration of the dual nature of vitamin B in 1926 (1, 2) which has been amply confirmed in recent years (35), there has been no satisfactory method for the separation of the heat-labile antineuritic (vitamin B,) from the more heat-stable growth-promoting (vitamin B,) component of the vitamin B complex. There are numerous experiments recorded in the lit,erature indicating that at l...

The effect of vitamin B-complex on cadmium nephrotoxicity and hepatotoxicity was investigated in rats. The administration of Cd (3 mg per kg, s.c., three days) increased the urinary excretions of lactic dehydrogenase (LDH), glutamic oxalacetic transaminase (GOT), and total proteins, decreased renal activities LDH and GOT and increased concentration in kidney tissue of Cd, Cu, and Zn, Cadmium al...

The experimental rations commonly used in studies on the vitamin B(2) complex are, as a rule, low in content of choline. Addition of vitamin B(6) has an aggravating influence on the specific effect of deficiency of choline, especially with regard to the development of cortical necrosis of the kidneys. The acute and subacute lesions associated with this specific type of renal injury are describe...

In forty-eight rats kept on a basal diet deficient in the vitamin B complex and supplemented with vitamin B(1) and riboflavin or with vitamin B(1), riboflavin and vitamin B(6), various pathological changes in the liver were observed. These changes were characterized mainly by parenchymatous and fatty degeneration, focal and massive necrosis, hyperemia and hernorrhage and, in some of the rats, b...