A new series of bis-benzimidazole derivatives was designed and synthesized. In vitro cytotoxity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 8 owned the best potential, its IC50 values being 0.58 μM (mononuclear tumor cell line (U937)) and 0.56 μM (cervical cancer cell (Hela)), respectively. Molecular modeling, fluorescenc...

The deformability of erythrocytes from smoking and non-smoking human subjects was examined by filtration through 3-mu pores and capillary viscometry of cell suspensions. In both cases, small but significant differences were found between the two groups that are consistent with a reduction in the surface area-to-volume ratio and/or a diminished membrane flexibility in erythrocyte from smokers. A...

The formation of polyelectrolyte complexes between carboxymethylcellulose and N-methylated poly(2-vinylpyridine), at a nonstoichiometric mixing ratio, was studied. Various methods, such as viscometry, turbidimetry, electrophoresis, and optical spectroscopy, were used to investigate the complexes with respect to their composition, structure, and stability in aqueous systems of different ionic st...