Avian paramyxoviruses (APMV) serotypes 1-9 are frequently isolated from domestic and wild birds worldwide. APMV-1 (also called Newcastle disease virus, NDV) is attenuated in non-human primates and is being developed as a candidate human vaccine vector. The vector potential of the other serotypes was unknown. In the present study, we evaluated nine different biologically- or recombinantly-derive...

Background Significantly higher pharyngeal shedding of Epstein-Barr virus (EBV) is observed during HIV infection. Increased EBV shedding in pharynx is not affected even during highly active antiretroviral theyrapy (HAART). EBV positive monocyte populations have been shown to carry EBV to pharyngeal mucosa. Human cytokine profiles are often altered to facilitate herpes virus infection. Thus phar...

Influenza virus infection poses a considerable risk for complications to the general population and in particular to solid organ transplant recipients (SOTR). Life-long immunosuppression in SOTR likely contributes to delayed clearance of influenza virus from the airways: Prolonged Viral Shedding (PVS) has important implications for potential infectivity and infection control measures. Duration ...

BACKGROUND The association between initiation of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection and possible herpes simplex virus type 2 (HSV-2) shedding and genital ulcer disease (GUD) has not been evaluated. METHODS GUD and vaginal HSV-2 shedding were evaluated among women coinfected with HIV and HSV-2 (n = 440 for GUD and n = 96 for HSV-2 shedding) who began ...

Background & Aims: The H9N2 avian influenza subtype is endemic in many parts of Iran and has the ability to transmit from bird to human. In the present study, the risk of this subtype for humans was assessed by determination of the viral titer and shedding time in bird. Method: The experiment was done on fifteen male budgerigars at 4 months of age. The birds w...

Background & Aims: The H9N2 avian influenza subtype is endemic in many parts of Iran and has the ability to transmit from bird to human. In the present study, the risk of this subtype for humans was assessed by determination of the viral titer and shedding time in bird. Method: The experiment was done on fifteen male budgerigars at 4 months of age. The birds were inoculated intranasally with al...

Newcastle disease (ND) leading to heavy economic losses to the poultry industry worldwide is caused by Newcastle disease virus (NDV). Even though intensive vaccination programs have been implemented in many countries, virulent NDV can still be frequently isolated in well-vaccinated flocks. We compared the protection efficiency of LaSota and two sub-genotype VIId vaccines, NDV/AI4 and NDV O/AI4,...

OBJECTIVE To characterize the probability and duration of viral shedding among adults given trivalent live attenuated influenza vaccine (LAIV). DESIGN Prospective surveillance study. METHODS Nasal wash samples were collected from adult volunteers at baseline and on days 3, 7, and 10 and between days 17 and 21 following intranasal LAIV vaccination. The presence, titer, and identification of ...