High pathogenicity avian influenza (HPAI) is a viral disease with devastating consequences for the poultry industry worldwide. Domestic ducks are major source of HPAI viruses in many Eurasian countries. The infectivity and vary depending on host factors. To assess factors influencing ducks, we compared pathobiology two (H5N1 clade 2.3.2.1c H5N6 2.3.4.4e) 5- 25-week-old ducks. Both caused mortal...

We have previously found that whole influenza virus vaccine induced a more rapid and stronger humoral response, particularly after the first dose of vaccine, than split virus vaccine in mice. In this study, we have evaluated the protective efficacy of whole and split influenza virus vaccines in mice using a nonlethal upper respiratory tract challenge model. We have also investigated the immunol...

PURPOSE Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer. We conducted a first-in-human, first-in-class phase I clinical trial of this agent in patients with cancers with neuroendocrine features, including small cell lung cancer. EXPERIMENTAL ...

background: the shielding methods in radiotherapy due to delivering an accurate radiation dose to cancer tissues and avoiding unnecessary dose to normal tissues are very important. these methods include lead standard blocks, individual molding and multi leaf collimator (mlc). the mlc method is not still common in iran radiotherapy centers. individual molding is better than the lead block shield...

primary hepatic lymphoma (phl) is rare and possibly associated with viral hepatitis and autoimmune diseases. scleroderma could exceptionally be complicated by lymphoma. we describe phl occurring in a 52-year-old female suffering scleroderma for eight years, with no history of cytotoxic or high-dose glucocorticoid therapy. ct scan, performed to work-up abdominal discomfort, constipation, and ele...

background: natural background radiation of a particular region is one of the distinctive factors defining the status of environment. eloor island is an industrial area in ernakulum district of the state of kerala, india. the indoor and outdoor gamma level measurements have been carried out for the region for evaluating the annual effective dose to the population residing in this area. material...