We have isolated fifty-two endophytic fungi (AA-CRL-1 to AA-CRL52) from the leaves of Catharanthus roseus plants collected from different parts of Pune (Maharashtra, India). These endophytic fungi represented different genera and were screened for vinca alkaloids production using TLC and ESI-MS analysis. Out of the 52 endophytic fungal cultures screened, the endophytic culture AA-CRL-20 was fou...

The paper presents a service composition language called VINCA, which differs from many existing ones in its emphasis on enabling business users to visually “program” from business view-point their personalized applications on the basis of Web-based services. VINCA embodies an integrated approach to mediating between diverse, rapidly changing user requirements and composites of individual servi...

Chemotherapy induced peripheral neuropathy (CIPN), a side effect of many anti-cancer drugs including the vinca alkaloids, is characterized by a severe pain syndrome that compromises treatment in many patients. Currently there are no effective treatments for this pain syndrome except for the reduction of anti-cancer drug dose. Existing data supports the model that the pain associated with CIPN i...

The suitability of neurons of the freshwater snail Lymnaea stagnalis as a test system for the neurotoxic side effects of antitumour Vinca alkaloids has been investigated, by studying the process of paracrystal induction by Vinca antitumour agents. Three Vinca alkaloids have been compared: the natural vinblastine and vincristine and the semisynthetic vindesine. They appear to induce two types of...

This study was performed on an alfalfa crop located on the central plain of La Araucanía Region, Chile and in the Laboratorio de Entomología Aplicada de la Facultad de Ciencias Agropecuarias y Forestales at the Universidad de La Frontera. Certain aspects of the biology of Hippodamia variegata (Goeze) (Coleoptera: Coccinellidae) were determined, more specifically in relation to its life cycle, s...

Bauhinia variegata L. is traditionally used in treating a variety of ailments in India. Phytochemical screening and in vitro free radical scavenging activity of aqueous and ethanolic bark extracts of Bauhinia variegata was assessed by studying its ability to scavenge DPPH, Nitric oxide, hydroxyl radical and reducing power. Phytochemical analysis revealed the presence of steroid, phenol/ tannin,...

Ten species of the genus Lista are recognized from China. Among them, five species are described as new to science, namely, Lista angustusasp. n., Lista gilvasasp. n., Lista longifundamenasp. n., Lista menghaiensissp. n., and Lista sichuanensissp. n. Diagnoses are provided for the genus and five previously described species, Lista haraldusalis (Walker, 1859), Lista insulsalis (Lederer, 1863), L...

indole ahloids of vinca species are valued greatly in medical sciences, one reason being for their use as powerful anticancer agents. there are four species of vinca in iran: v. rosea, v. major, v. minor and v. herbacea. in previous investigations, we found that these plants have considerable alkaloid similarity (58.8- 75%). therefore, chromosomic and electrophuretic studies followed after inve...

Vinca alkaloids are well known for their antimitotic and antitumor activities. It inhibits transcription and translation 0, 2, 3). Vinca alkaloids cause specific mitotic arrest of cells. The drugs derived from these alkaloids are: Vinblastine and vincrystine. These drugs have been extensively used for studying the nature of cell arrest and the associated changes in various clinical (neoplastic ...