نتایج جستجو برای: vimentin

تعداد نتایج: 6516  

Journal: :Journal of Cell Biology 2002

Journal: :Development 1989
J A Dent A G Polson M W Klymkowsky

We have developed a whole-mount immunocytochemical method for Xenopus and used it to map the expression of the intermediate filament protein vimentin during early embryogenesis. We used two monoclonal antibodies, 14h7 and RV202. Both label vimentin filaments in Xenopus A6 cells, RV202 reacts specifically with vimentin (Mr, 55 x 10(3] on Western blots of A6 cells and embryos. 14h7 reacts with vi...

2017
Yong Hu Jialan Zang Xiaobing Qin Dali Yan Haixia Cao Leilei Zhou Jie Ni Shaorong Yu Jianzhong Wu Ji-Feng Feng

The role of epithelial-to-mesenchymal transition in cancer drug resistance is increasingly acknowledged. We examined whether epithelial-to-mesenchymal transition affects gefitinib resistance in non-small cell lung cancer (NSCLC) cells. Cell viability was detected by CCK-8 assay, VIM expression levels were determined by quantitative real-time polymerase chain reaction. Western blot and immunocyt...

Journal: :PLoS Pathogens 2009
Kristopher J. Koudelka Giuseppe Destito Emily M. Plummer Sunia A. Trauger Gary Siuzdak Marianne Manchester

Cowpea mosaic virus (CPMV) is a plant comovirus in the picornavirus superfamily, and is used for a wide variety of biomedical and material science applications. Although its replication is restricted to plants, CPMV binds to and enters mammalian cells, including endothelial cells and particularly tumor neovascular endothelium in vivo. This natural capacity has lead to the use of CPMV as a senso...

2016
Michiko Shigyo Chihiro Tohda

Vimentin, an intermediate filament protein, is an intracellular protein that is involved in various cellular processes. Several groups have recently reported that vimentin also appears in the extracellular space and shows novel protein activity. We previously reported that denosomin improved motor dysfunction in mice with a contusive spinal cord injury (SCI). At the injured area, astrocytes exp...

2011
Nicole F. Steinmetz Jochen Maurer Huiming Sheng Armand Bensussan Igor Maricic Vipin Kumar Todd A. Braciak

Vimentin was originally identified as an intermediate filament protein present only as an intracellular component in many cell types. However, this protein has now been detected on the surface of a number of different cancer cell types in a punctate distribution pattern. Increased vimentin expression has been indicated as an important step in epithelial-mesenchymal transition (EMT) required for...

Journal: :basic and clinical cancer research 0
sanaz rismanchi cancer biology research center, cancer institute, tehran university of medical sciences, tehran, iran ahad muhammadnejad cancer research center, cancer institute, tehran university of medical sciences, tehran, iran elahe keyhani genetics research center, university of social welfare & rehabilitation sciences, tehran, iran samad muhammadnejad research center for molecular and cellular imaging, tehran university of medical sciences, tehran, iran saeid amanpour cancer biology research center, cancer institute, tehran university of medical sciences, tehran, iran

background: for xenograft models of triple-negative breast cancer (tnbc) to be valuable in development of molecularly-targeted drugs, careful characterization is essential to their validation. the present study aimed to validate the tnbc xenograft model with a specific focus on angiogenesis. methods : twelve tnbc xenograft tumors and 12 human breast cancer tumors (htnbc) were included in this s...

Journal: :Cell reports 2015
Yaming Jiu Jaakko Lehtimäki Sari Tojkander Fang Cheng Harri Jäälinoja Xiaonan Liu Markku Varjosalo John E Eriksson Pekka Lappalainen

The actin cytoskeleton and cytoplasmic intermediate filaments contribute to cell migration and morphogenesis, but the interplay between these two central cytoskeletal elements has remained elusive. Here, we find that specific actin stress fiber structures, transverse arcs, interact with vimentin intermediate filaments and promote their retrograde flow. Consequently, myosin-II-containing arcs ar...

Journal: :Infection and immunity 1989
J Coburn S T Dillon B H Iglewski D M Gill

Exoenzyme S, which had been thought to be unselective, catalyzes the ADP-ribosylation of only a subset of cellular proteins. The intermediate filament protein vimentin is one of the more abundant substrates. Disassembled vimentin, and proteolytic fragments of vimentin that cannot form filaments, is more readily ADP-ribosylated than is filamentous vimentin.

2016
P. P. Mahesh R. J. Retnakumar Sathish Mundayoor

Mycobacterium tuberculosis persists primarily in macrophages after infection and manipulates the host defence pathways in its favour. 2D gel electrophoresis results showed that vimentin, an intermediate filament protein, is downregulated in macrophages infected with live Mycobacterium tuberculosis H37Rv when compared to macrophages infected with heat- killed H37Rv. The downregulation was confir...

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