A ctivation of leukocytes may play a part in the / \ complex pathophysiological cascade leading to A.V. vasomotor reaction in cerebral arteries. In this issue of Stroke, Akopov et al report changes in endothelium-dependent relaxation by intravascular chemical leukocyte activation involving the cerebral circulation. This interesting study highlights a potential role for leukocytes in the modulat...

BACKGROUND The precise etiology of border zone infarcts is controversial. Hemodynamic impairment due to obstructive disease of the internal carotid artery (ICA) is suggested as a cause of border zone infarcts. OBJECTIVE To investigate changes in prevalence and volume of ischemic border zone lesions over time in patients with occlusive disease of the ICA after 1 year of follow-up. DESIGN Fol...

BACKGROUND AND PURPOSE The use of flow velocity changes in the middle cerebral artery (MCA) measured by Doppler techniques as an index of corresponding cerebral blood flow (CBF) changes is based on the assumption that the insonated arterial diameter remains stable. The postulate of unchanging vessel calibers during CBF changes, however, is still under debate. We performed simultaneous measureme...

Previous work from our laboratory has demonstrated that the very low-frequency (VLF: 0-0.25 Hz) and low-frequency (LF: 0.25-0.8 Hz) power of arterial pressure variability (APV) are related to vasomotor reactivity in response to control signals from the rostral ventrolateral medulla (RVLM) via the sympathetic system in the rat. The present study evaluated the differences in the dynamic property ...

Abstract Background Three AD Centers have joined together to study the regulation of cerebral perfusion at resting conditions using spontaneous time‐series data with a modeling methodology that previously yielded indications reduced dynamic vasomotor CO2 reactivity in amnestic MCI patients [ Marmarelis et al., J. Alzh. Dis. 56:89–105, 2017 ] and significant correlation this reduction functional...

BACKGROUND Abnormal vascular reactivity represents a fundamental disturbance in vascular biology with the development of atherosclerosis. Because endothelial vasodilator function plays a pivotal role in controlling vasomotor tone, we hypothesized that atherosclerotic wall thickening might directly interfere with deficient endothelium-mediated dilation and thereby contribute to the abnormal reac...