insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome x, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. insulin resistance can be induced by fructose-rich diet in rats. we investigated the effect of vanadyl sulfate (0.2 mg...

A series of chiral vanadyl carboxylates derived from N-salicylidene-L-alpha-amino acids and vanadyl sulfate has been developed. These configurationally well defined complexes were examined for the kinetic resolution of double- and mono-activated 2 degrees alcohols. The best chiral templates involve the combination of L-tert-leucine and 3,5-di-t-butyl-, 3,5-diphenyl-, or 3,4-dibromo-salicylaldeh...

carbon paste electrode was modified by disodium 2,4-diamino-7-methylbenzo[g] pteridine-5,10-dioxide to fabricate a sensor for potentiometric determination of vanadyl ion (vo2+) in aqueous medium. the new ligand was synthesized in three steps with high yield. the optimal composition of the carbon paste was made of graphite powder (64.5%), ionophore (16.6%), paraffin oil (17.8%), and sodium tetra...

Since insulin-dependent diabetes mellitus (IDDM), which causes many severe secondary complications, is characterized by hyperglyceria due to absolute deficiency of insulin, the diseases is controlled by daily injection of insulin. Therefore, the development of insulin replacements of mimetics upon oral administration is an important investigation. Recent studies indicate that vanadium, which is...

To determine whether insulin resistance and hyperinsulinemia are causally related to fructose-induced hypertension, we used vanadyl sulfate, a drug that improves insulin sensitivity in rats. Chronic oral vanadyl treatment was initiated in 6-week-old male Sprague-Dawley rats. One week after vanadyl was started, rats were fed either normal rat chow or a fructose-enriched diet. Plasma glucose and ...

Carbon paste electrode was modified by disodium 2,4-diamino-7-methylbenzo[g] pteridine-5,10-dioxide to fabricate a sensor for potentiometric determination of vanadyl ion (VO2+) in aqueous medium. The new ligand was synthesized in three steps with high yield. The optimal composition of the carbon paste was made of graphite powder (64.5%), ionophore (16.6%), paraffin oil (17.8%), a...

BACKGROUND The National Toxicology Program (NTP) performed short-term toxicity studies of tetra- and pentavalent vanadium compounds, vanadyl sulfate and sodium metavanadate, respectively. Due to widespread human exposure and a lack of chronic toxicity data, there is concern for human health following oral exposure to soluble vanadium compounds. OBJECTIVES To compare the potency and toxicologi...

The mode of chiral interaction between a series of asymmetric epoxides (propylene oxide, butylene oxide, epifluorohydrin and epichlorohydrin) and a chiral vanadyl salen complex, N, N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino-vanadium (iv) oxide, [VO()], was investigated by a range of electron magnetic resonance techniques (EPR, ENDOR, HYSCORE) and DFT. Enantiomer discriminatio...

OBJECTIVE Vanadyl sulphate, an inorganic tetravalent salt of transition metal vanadium is conventionally used to treat diabetes and by athletes as body-building supplement. Vanadyl sulphate is a constituent of many supplements and herbal preparations available over the counter in many parts of the world. In this study the efficacy of the salt as hypoglycaemic agent and its effects on lipid prof...