BACKGROUND The expected value of partial perfect information (EVPPI) is a theoretically justifiable and informative measure of uncertainty in decision-analytic cost-effectiveness models, but its calculation is computationally intensive because it generally requires two-level Monte Carlo simulation. We introduce an efficient, one-level simulation method for the calculation of single-parameter EV...

Deterministic mine planning models along a time horizon have proved to be very effective in supporting decisions on sequencing the extraction of material in copper mines. Some of these models have been developed for, and used successfully by CODELCO, the Chilean state copper company. In this paper, we wish to consider the uncertainty in a very volatile parameter of the problem, namely, the copp...

With reference to the discussion about shareholder versus stakeholder maximization it is argued that the normal type of maximization is in fact stakeholder-owner maximization. This means maximization of the sum of the value of the shares and stakeholder benefits belonging to the dominating stakeholder-owner. Maximization of shareholder value is a special case of owner-maximization, and only und...

Accurate measurement of longitudinal changes of brain structures and functions is very important but challenging in many clinical studies. Also, across-subject comparison of longitudinal changes is critical in identifying disease-related changes. In this paper, we propose a novel method to meet these two requirements by simultaneously registering sets of longitudinal image sequences of differen...