OBJECTIVES Bihar, the poorest state in India, concentrates most of the visceral leishmaniasis (VL) cases in the country. A large proportion of the poor rural communities where VL is endemic are marginalized by their socio-economic status, intrinsically related to the caste system. In this study, we evaluated whether people from low socio-economic strata had difficulties accessing VL treatment i...

BACKGROUND & OBJECTIVES Despite remarkable progress in airborne, vector-borne and waterborne diseases in India, the morbidity associated with these diseases is still high. Many of these diseases are controllable through awareness and preventive practice. This study was an attempt to evaluate the effectiveness of a preventive care awareness campaign in enhancing knowledge related with airborne, ...

The present investigation was carried out in a holistic mode to study the interactions among integrated farming system (IFS) components and develop design sustainable IFS model which is technologically sound, economically viable, environmentally benign, socially acceptable for middle Indo-Gangetic Plains. For efficient utilization of farm resources enhance income per unit area land, 10 models h...

The present study deals with the development of an accurate, economical and reproducible UV spectrophotometric method for the simultaneous estimation of abacavir, lamivudine and zidovudine in pure bulk drug and in combined tablet dosage form. The stock solutions were prepared in acetonitrile followed by the further required dilutions with distilled water. The λ max for abacavir, lamivudine, and...

OBJECTIVE We sought to estimate visceral leishmaniasis (VL) burden in Bangladesh, India, and Nepal and document care-seeking behaviour for VL to provide baseline information for monitoring the VL elimination program and identify options for improved case finding and management. DESIGN A cross-sectional study using cluster sampling (clusters being villages) of 4 VL endemic districts was used i...

i ii iii iv Dedicated to my mother… v ACKNOWLEDGEMENTS This thesis would simply not have been possible without the work, guidance and endless belief and support of my guide Dr. S. Vijayalakshmi. She really did show me what it takes to pursue research and kept me going. Her patient, modest and kind nature helped me understand and do better. Her warm words of appreciation and encouragement made m...

Background Signal transducer and activator of transcription 3 (STAT3) is a factor that belongs to class targets devoid catalytic function, thus deemed “undruggable” by standard modalities such as small molecule inhibitors or biologics. STAT3 can be activated various receptor- non-receptor tyrosine kinases, playing critical role in activation pathways triggered cytokines, hormones, growth factor...

I mmunoglobulin (Ig)-mediated kidney disorders can be divided into those that result from deposition into the kidney of intact Ig molecules and those caused by components of Ig molecules—usually light chains or light chain fragments, and, less frequently, heavy chains or heavy chain fragments. In the intact Ig disorders, such as IgA nephropathy, membranous nephropathy, lupus nephritis, and anti...

TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Carbon Monoxide (CO) is a colorless, odorless gas found in fumes produced from carbon fuels engines, stoves, and fireplaces. CO binds to hemoglobin forming molecule called carboxyhemoglobin (CO-Hb), which has higher affinity O2 than itself leads symptoms of hypoxia ischemia. Given an adequate history, clinicians can ...

Background Tyrosine kinase 2 (TYK2) mediates signaling of Type I interferons, IL-23, and IL-12, key cytokines involved in lupus pathogenesis. Deucravacitinib (DEUC) is an oral, selective, allosteric TYK2 inhibitor with a unique mechanism action, distinct from Janus (JAK) 1/2/3 inhibitors, has shown efficacy psoriasis psoriatic arthritis. Objectives Assess safety DEUC patients active systemic er...