Intravaginal infection with C. muridarum in mice often results in hydrosalpinx similar to that found in women urogenitally infected with C. trachomatis, making the C. muridarum lower genital tract infection murine model suitable for studying C. trachomatis pathogenesis. To our surprise, DBA1/j mice were highly resistant to hydrosalpinx following an intravaginal infection with C. muridarum altho...

Infection is a significant cause of preterm birth. Abnormal changes in intracellular calcium signals are the ultimate triggers of early uterine contractions that result in preterm birth. T‑type calcium channels play an important role in the pathogenesis of cancer, as well as endocrine and cardiovascular diseases. However, there are limited studies on their role in uterine contractions and partu...

We report the case of a second gesture, second parity 42-year old patient, undergoing surgical treatment for interstitial uterine myoma. The postoperative course was marked by a skin infection associated with uterine eventration. On physical examination, the patient was febrile (39.5 °C) with evisceration of the uterus and green pus discharge from the surgical site. Laboratory tests showed a he...

At the uterine-placental interface, fetal cytotrophoblasts invade the decidua, breach maternal blood vessels, and form heterotypic contacts with uterine microvascular endothelial cells. In early gestation, differentiating- invading cytotrophoblasts produce high levels of matrix metalloproteinase 9 (MMP-9), which degrades the extracellular matrix and increases the invasion depth. By midgestation...

This study was conducted to investigate the effects of infusion of 1% Lugols iodine into infected uteri of postpartum (PP) dairy cows on uterine involution (UI), appearance of the first dominant follicle (DF), recrudescence of the first oestrus (FO), days open (DO), rate of service per conception and calving interval (CI). Forty dairy cows that were diagnosed with severe uterine bacterial infec...

Infection with Chlamydia trachomatis targets epithelial cells within the genital tract which respond by secreting chemokines and cytokines. Persistent inflammation can lead to fibrosis, tubal infertility and/or ectopic pregnancy; many infections are asymptomatic. Most studies have investigated the inflammatory response in the initial stages of infection, less is known about the later stages of ...

Puerperal uterine inversion is an uncommon but life threatening obstetrical emergency. A 26-year-old woman, para six, was referred from a peripheral hospital seven days after delivery, with a mass protruding per vaginum. Complete uterine inversion had occurred after delivery of baby and placenta. She was resuscitated and her genital infection was treated. She had a vaginal hysterectomy upon req...

Infection with Chlamydia trachomatis targets epithelial cells within the genital tract which respond by secreting chemokines and cytokines. Persistent inflammation can lead to fibrosis, tubal infertility and/or ectopic pregnancy; many infections are asymptomatic. Most studies have investigated the inflammatory response in the initial stages of infection, less is known about the later stages of ...

Intra-uterine and oral temperatures were recorded in 23 patients with fetal tachycardia during labour, as well as in 22 patients without fetal tachycardia. In the tachycardia group, the mean intra-uterine temperature was 38,83 degrees C, against 37,44 degrees C in the control group. The oral temperatures were 38,05 degrees C and 33,98 degrees C respectively. Furthermore, a high incidence of neo...

Mice with the type I interferon (IFN) receptor gene knocked out (IFNAR KO mice) or deficient for alpha/beta IFN (IFN-α/β) signaling clear chlamydial infection earlier than control mice and develop less oviduct pathology. Initiation of host IFN-β transcription during an in vitro chlamydial infection requires interferon regulatory transcription factor 3 (IRF3). The goal of the present study was t...