Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preecla...

Preeclampsia and fetal growth restriction are major causes of perinatal mortality and morbidity. Several studies have shown that a generalized endothelial dysfunction is associated with these complications. Clinical trials have shown that pregnant women who demonstrate high resistance in uteroplacental blood flow are at higher risk for preeclampsia. Uterine artery Doppler studies both in the se...

The authors implied that the abnormal uterine artery Doppler velocimetry is one of the risk markers for preeclampsia in the second or third trimester and that its abnormality is practically defined at 22–24 weeks as bilateral notching with mean resistance index (RI) > 0.55 (i.e., > 50th centile), unilateral notching with mean RI > 0.65 (> 90th centile), or no notching with mean RI > 0.70 (> 95t...

OBJECTIVE To assess the role of Doppler uterine artery screening in the prediction of recurring hypertensive disorders in a high-risk population. METHODS Ninety-four women with a history of hypertensive disorders in previous pregnancies underwent ultrasound color Doppler to analyze blood flow in the uterine arteries at 21-22 weeks of gestation. We evaluated the performance of the Pulsatility ...

BACKGROUND: To study the utility of uterine artery Doppler flow velocimetry in 2nd trimester in prediction of preeclampsia in high risk and low risk women. MATERIALS AND METHODS: 200 women carrying <16weeks of pregnancy with singleton fetus and without any fetal anomaly were recruited and were divided in high-risk and low-risk group. Doppler velocimetry of uterine artery was done at 24-26 weeks...

OBJECTIVE To relate Doppler velocimetry findings in fetoplacental and uteroplacental circulation to placental histomorphology. MATERIAL AND METHODS In 14 uncomplicated and 31 high-risk pregnancies Doppler velocimetry was performed in umbilical artery and vein, and in maternal uterine veins and arteries during the second half of gestation. Histopathology of the placentas was examined, especial...

background: we conducted this prospective study to evaluate the prognostic significance of uterine and ovarian artery doppler velocimetry in clomiphene citrate (cc) cycles. materials and methods: a total of 80 patients with unexplained infertility were given 100 mg/day of cc from day 3 to day 7 of their cycles in this current prospective study. on cycle day 3, before administration of cc, each ...

BACKGROUND Increased impedance to flow in the uterine arteries assessed by value of the Doppler is associated with adverse pregnancy outcomes, especially pre-eclampsia. We investigated the predictive value of a uterine artery Doppler in the identification of adverse pregnancy outcomes such as 'pre-eclampsia' and 'small fetus for gestational age' (SGA). MATERIALS AND METHODS Three hundred and ...

OBJECTIVES To determine the accuracy with which uterine artery Doppler in the first trimester of pregnancy predicts pre-eclampsia and fetal growth restriction, particularly early-onset disease. METHODS We searched MEDLINE (1951-2012), EMBASE (1980-2012) and the Cochrane Library (2012) for relevant citations without language restrictions. Two reviewers independently selected studies that evalu...

BACKGROUND Alterations in waveforms in the uterine artery are associated with the development of pre-eclampsia and intrauterine growth restriction. We investigated the predictive accuracy of all uterine artery Doppler indices for both conditions in the first and second trimesters. METHODS We identified relevant studies through searches of MEDLINE, EMBASE, the Cochrane Library and Medion datab...