The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventiona...

Brown trout growth in Minnesota streams as related to landscape and local factors Andrew K. Carlson, William E. French, Bruce Vondracek, Leonard C. Ferrington Jr, Jane E. Mazack & Jennifer L. Cochran-Biederman To cite this article: Andrew K. Carlson, William E. French, Bruce Vondracek, Leonard C. Ferrington Jr, Jane E. Mazack & Jennifer L. Cochran-Biederman (2016): Brown trout growth in Minneso...

OBJECTIVE Assess the impact of infusion pump technologies (traditional pump vs smart pump vs smart pump with barcode) on nurses' ability to safely administer intravenous medications. DESIGN Experimental study with a repeated measures design. SETTING High-fidelity simulated inpatient unit. RESULTS The nurses remedied 60% of "wrong drug" errors. This rate did not vary as a function of pump ...

Cochran constructed many links with Alexander module that of the unlink and some nonvanishing Milnor invariants, using as input commutators in a free group and as an invariant the longitudes of the links. We present a different and conjecturally complete construction, that uses elementary properties of clasper surgery, and a different invariant, the tree-part of the LMO invariant. Our method al...

BACKGROUND Examining seasonal patterns of birth defects may help to identify environmental risk factors. Because the teratogenic window for most birth defects is during gestational weeks 3 to 8, investigating exposures closer to the timing of conception is important. However, studies are usually based on month of birth, which is not the biologically relevant exposure period and does not account...

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