Objective: To determine how the balance between mineral base, and carbonic and organic acids is altered to cause metabolic acidosis in preterm infants. Study Design: Mineral balance and arterial blood measurements of 3 groups of preterm infants given 5 different Total Parenteral Nutrition (TPN) regimens were analyzed. Mineral base was measured as the difference between mineral cations and anion...

After intravenous injection of S-adenosyl-L-homocysteine3H (homocysteine-labeled) into rats, less than 15% of the radioisotope was incorporated into protein methionine or excreted in the urine as oc-ketobutyrate. The remaining radioisotope was found associated with an unknown keto acid excreted in the urine. Intravenous injection of Sadenosyl-L-homocysteine-35S or S-adenosyl-3H-L-homocysteine (...

Jamaican vomiting sickness is characterized by sudden-onset acute vomiting and diarrhoea with profound hypoglycaemia, leading t o coma and death. Pathological changes observed include fatty infiltration of the viscera, and similarities with Reye’s syndrome (encephalopathy and fatty degeneration of the viscera) have been noted (Lowry, 1975). Recently, twin siblings presented in Harrow with a n u...

Meralluride, mercaptomerin, ethacrynic acid, and penicillamine inhibited urease activity of Proteus mirabilis. The activity of the organic mercurials and ethacrynic acid was markedly inhibited by human and dog urine. Antiurease activity could not be detected in the urine of a human and a dog given meralluride by injection. Urine from patients receiving penicillamine also failed to inhibit ureas...

HE RECENT EMPHASIS on disorders of acid-base metabolism has necessitated a reappraisal of those urinary constituents which represent elimination of acid or base. The conventional expression for urinary acid excretion (“net acid excretion”) is titratable acid bicarbonate + ammonia (T.A. CO2 + NH4 ) (1). It has been the contention of this laboratory that acid excretion is more inclusively represe...

BACKGROUND Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a rare inherited mitochondrial fatty acid oxidation disorder associated with variations in the ACADS (Acyl-CoA dehydrogenase, C-2 to C-3 short chain) gene. SCADD has highly variable biochemical, genetic and clinical characteristics. Phenotypes vary from fatal metabolic decompensation to asymptomatic individuals. SUBJECT AND M...

Amantadine transport into renal proximal and distal tubules is bicarbonate dependent. In the present study, we addressed the effects of bicarbonate on renal clearance and urinary excretion of amantadine. Renal clearance of kynurenic acid was also studied to determine whether bicarbonate effects are specific for organic base transport by the kidney. After a moderate diuresis was established, ani...