It is possible by means of repeated injections of uranium nitrate to produce in the cat a subacute or chronic nephritis which can progress to a fatal termination and show in its course increasing accumulation of non-protein nitrogen in the blood. This nephritis differs only slightly from the spontaneous chronic nephritis of the species. Repeated doses of diphtheria toxin produce a subacute form...

Uranyl complexes of a bis(methylterephthalamide) ligand (LH(4)) have been synthesized and characterized by X-ray crystallography. The structure is an unexpected [Me(4)N](8)[L(UO(2))](4) tetramer, formed via coordination of the two MeTAM units of L to two uranyl moieties. Addition of KOH to the tetramer gave the corresponding monomeric uranyl methoxide species [Me(4)N]K(2)[LUO(2)(OMe)].

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estimate the dose of imipenem required to induce an observable but nonlethal EEG ef...

The title compound, [(UO(2))(2)Cl(2)(OH)(2)(H(2)O)(4)], was obtained unintentionally as the product of an attempted reaction between uranium(VI) oxide dihydrate, UO(3)·2H(2)O, and hydrogen bis-(trifluoro-methyl-sulfon-yl)imide (HTf(2)N), in an experiment to obtain crystals of uranyl bis-(trifluoro-methyl-sulfon-yl)imide, UO(2)(Tf(2)N)(2)·xH(2)O. The structure consists of neutral dimers of urany...

Penta-ammine dioxide uranium(V) nitrate ammonia (1/1), [UO2(NH3)5]NO3·NH3, was obtained in the form of yellow crystals from the reaction of caesium uranyl nitrate, Cs[UO2(NO3)3], and uranium tetra-fluoride, UF4, in dry liquid ammonia. The [UO2]+ cation is coordinated by five ammine ligands. The resulting [UO2(NH3)5] coordination polyhedron is best described as a penta-gonal bipyramid with the O...

The solid-sate structures of the two uranyl peroxides studtite, [UO2(η(2)-O2)(H2O)2]·2H2O, and metastudtite [UO2(η(2)-O2)(H2O)2] have been determined by U-L3 edge extended X-ray absorption fine structure (EXAFS) spectroscopy and show that upon removal of the interstitial water in studtite there are structural changes with a small shortening of the U-O(peroxo) and small lengthening of the U-O(yl...

density distribution has recently been directly demonstrated in electron micrographs of formaldehyde-fixed SIS-type aggregates by Kuhn, K., U. Hofmann, and W. Grassmann (Naturwiss., 46, 512 1959). I For this purpose the segments were stained by exposure to 0.002 M uranyl nitrate for 1 minute and washed with distilled water before drying on the grid. Under these conditions the uranium in solutio...

A number of xenobiotics and certain pathophysiological situations cause the induction of CYP2E1. The present study was designed to establish the role of plasma urea nitrogen and L-arginine on hepatic CYP2E1 expression in rats or rats with acute renal failure. Exposure of rats to a single intravenous dose of 5 mg/kg uranyl nitrate caused renal failure in 5 days (ARF), as evidenced by increases i...

The reaction of uranyl nitrate hexahydrate with the maleonitrile containing Schiff base 2,3-bis[(4-diethylamino-2-hydroxybenzylidene)amino]but-2-enedinitrile (salmnt((Et(2)N)(2))H(2)) in methanol produces [UO(2)(salmnt((Et2N)2))(H(2)O)] (1) where the uranyl equatorial coordination plane is completed by the N(2)O(2) tetradentate cavity of the (salmnt((Et(2)N)(2)))(2-) ligand and a water molecule...

Single DNA molecules can be rendered visible in the electron microscope by "staining" with water-soluble salts of heavy metals. The best results were obtained with lanthanum nitrate, uranyl acetate, and lead perchlorate. The molecules appear as filaments approximately 20 A wide. Their length was not determined, but it could be shown that it varied with the molecular weight of the DNA used. The ...