نتایج جستجو برای: uplcpdaesimsn anticancer antioxidant

تعداد نتایج: 126758  

Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of Egypt. The current study aimed at UPLC/PDA/ESI-MSn qualitative chemical profiling of the phytoconstituents underlining both antioxidant and cytotoxic activities of the bio-active fraction in comparison with the other fractions. It resulted in detection of several related compounds to prenylated flavonol ...

Journal: :The Pan African medical journal 2016
Jihène Sahli Meriam El Ghardallou Iheb Bougmiza Besma Henchiri Manel Limam Rim Mejdoub Ali Mtiraoui Thouraya Ajmi

INTRODUCTION Nowadays, the circuit of drugs is a plague. This situation may cause serious harm to patients. In this context, we conducted a study with the aim to describe and evaluate the circuit of anticancer drugs in a Tunisian regional hospital. METHODS This is an evaluative study of the risk of anticancer drugs, conducted over a period of 15 days during the year 2014 in the Department of ...

2014
Rupesh Dudhe Pramod Kumar Sharma Prabhakar Kumar Verma

BACKGROUND A series of 6-(substituted aldehyde)-3,4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-(hydroxymethyl) furan-2-yl)-4-phenylpyrimidine-2(1H)-one derivative (6A-6P) was synthesized from the 6-(substituted aldehyde)-4-phenylpyrimidine-2(1H)-one derivative (5A-5P) through following reaction mechanisms Claisen-Schmidt, Cyclization, and Satos fusion. The structures of the synthesized compounds wer...

2015
V P B REKHA

Trichosanthes species of the Cucurbitaceae family, fruits of this species are good potential sources of various phenolic compounds and antioxidants with anticancer, antiproliferative, cardioprotective and antioxidant properties. Many research studies on Trichosanthes species reported that it contains important protein constituent known as Ribosome Inactivating Protein (RIP), it helps in formula...

2017
Md. Asaduzzaman Khan Mousumi Tania Shangyi Fu Junjiang Fu

Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structur...

2012
Branislav Ranković Marijana Kosanić Tatjana Stanojković Perica Vasiljević Nedeljko Manojlović

The aim of this study was to investigate the chemical composition of acetone extracts of the lichens Toninia candida and Usnea barbata and in vitro antioxidant, antimicrobial, and anticancer activities of these extracts together with some of their major metabolites. The chemical composition of T. candida and U. barbata extracts was determined using HPLC-UV analysis. The major phenolic compounds...

2015
Naif Abdullah Al-Dhabi Mariadhas Valan Arasu Thankappan Sarasam Rejiniemon

This study aimed to investigate the in vitro antibacterial, antifungal, antibiofilm, antioxidant, and anticancer properties of isosteviol isolated from endangered medicinal plant Pittosporum tetraspermum. Pure compound was obtained and characterized by column chromatography followed by (1)H NMR, (13)C NMR, IR, and mass spectral analysis. The antimicrobial activities of the compound were assesse...

2016
Pei Y. Liu Nicholas Sokolowski Su T. Guo Faraz Siddiqi Bernard Atmadibrata Thomas J. Telfer Yuting Sun Lihong Zhang Denise Yu Joshua Mccarroll Bing Liu Rui H. Yang Xiang Y. Guo Andrew E. Tee Ken Itoh Jenny Wang Maria Kavallaris Michelle Haber Murray D. Norris Belamy B. Cheung Jennifer A. Byrne David S. Ziegler Glenn M. Marshall Marcel E. Dinger Rachel Codd Xu D. Zhang Tao Liu

BET bromodomain inhibitors are very promising novel anticancer agents, however, single therapy does not cause tumor regression in mice, suggesting the need for combination therapy. After screening a library of 2697 small molecule compounds, we found that two classes of compounds, the quinone-containing compounds such as nanaomycin and anti-microtubule drugs such as vincristine, exerted the best...

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