Unconventional protein export/secretion (UPE/UPS), in contrast to the classical ER-Golgi-dependent of proteins with a leader sequence (signal peptide), employs multiple means release leaderless cargoes (and some special cases, sequence) extracellular space. By far, two major types UPE have been classified, vesicle-independent and vesicle-dependent UPE. In former, can directly tr...

OBJECTIVE Islet transplantation alone is an alternative for the replacement of pancreatic endocrine function in patients with type 1 diabetes. The aim of our study was to assess the impact of the Edmonton immunosuppressive protocol (tacrolimus-sirolimus association) on kidney function. RESEARCH DESIGN AND METHODS Nineteen patients with type 1 diabetes and metabolic instability received islet ...

En esta investigación se obtuvo la enzima papaína a partir de látex tres especies del género Vasconcellea, V. chachapoyensis, heilbornii y pubescens, nativas región Amazonas en Perú. El extraído acondiciono con buffer acetato sodio, EDTA solución bisulfito sodio. La purificación realizó adaptando el método Andrade (2011), utilizó sulfato amonio para precipitación; etanol 96° dos etapas dilución...

BACKGROUND Over a 12-month period, adolescent heart-screening programs were performed for identifying at-risk adolescents for sudden cardiac death (SCD) in our community. Novel to our study, all adolescents received an abbreviated, ultraportable echocardiography (UPE). In this report, we describe the use of UPE in this screening program. METHODS AND RESULTS Four hundred thirty-two adolescents...

STUDY OBJECTIVES To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome. METHODS We studied prospectively 57 consecutive patients with PPE (empyema (EMP), complicated (CPE), and uncomplicated parapneumonic effusion (UPE)). SAA, CRP, TNF-α, IL-1β, and IL-6 levels were evaluated in serum...

Sulphur deficiency severely affects plant growth and their agricultural productivity leading to diverse changes in development and metabolisms. Molecular mechanisms regulating gene expression under low sulphur conditions remain largely unknown. AtSLIM1, a member of the EIN3-like (EIL) family was reported to be a central transcriptional regulator of the plant sulphur response, however, no direct...

BACKGROUND Proteinuria is well recognised as a marker of chronic kidney disease (CKD), as a risk factor for progression of CKD among those with known CKD, and as a risk factor for cardiovascular events and death among both the general and CKD populations. Which measure of proteinuria is most predictive of renal events remains uncertain. METHODS We conducted a prospective study with 144 protei...

Abstract Universal primary education (UPE) policies have been shown to improve educational attainment and delay marriage childbearing, particularly among rural girls. This disproportionate improvement in female relative male can change the bargaining structure between wife husband. Furthermore, with expectation of this change, decisions about marriage-market entry, matching, marital arrangement...

BACKGROUND In the past years, research on ultraweak photon emission (UPE) from human body has increased for isolated cells and tissues. However, there are only limited data on UPE from the whole body, in particular from the hands. OBJECTIVE To describe a protocol for the management of subjects that (1) avoids interference with light-induced longterm delayed luminescence, and (2) includes the ...