Description The gene contains five exons and four introns; it is composed of a variable 5' untranslated region, a 296 bp coding sequence, a 3' untranslated region and a polyA tail. Transcription The gene has 5 alternatively spliced variants encoding the same protein; the variant 1 represents the longest transcript (951 bp), all the other variants have distinct and shorter 5'UTR as compared to v...

Article history: Received 5 February 2016 Accepted 5 February 2016 Available online 6 February 2016 BMPR2 variants and COPD in a southern Chinese population (Wang et al., 2016). They investigated two polymorphisms in the 3′ untranslated region of the BMPR2 gene. The 3′ untranslated region of an mRNA molecule is the sequence following the termination codon and plays an important role in the regu...

MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A microRNA encoded by human cytomegalovirus downregulates MICB expression by targeting a specific site in the MICB 3¢ untranslated region. As this site is conserved among different MICB alleles and a similar site exists in the MICA 3¢ untranslated region, we speculated that these sites are targeted by cellular...

We have identified a cellular target for proteasomal endonuclease activity. Thus, 20 S proteasomes interact with the 3'-untranslated region of certain cytoplasmic mRNAs in vivo, and 20 S proteasomes isolated from Friend leukemia virus-infected mouse spleen cells were found to be associated with a mRNA fragment showing great homology to the 3'-untranslated region of tumor necrosis factor-beta mR...

Eukaryotic cells control their growth and morphogenesis to maintain integrity and viability. Free-living cells are further challenged by their direct interaction with the environment and in many cases maintain a resilient cell wall to stay alive under widely varying conditions. For these organisms, stringent and highly localized control of the cell wall's remodeling and expansion is crucial for...

In many eukaryotes, messenger RNAs with premature termination codons are destroyed by a process called "nonsense-mediated decay", which requires the RNA helicase Upf1 and also, usually, an interacting factor, Upf2. Recognition of premature termination codons may rely on their distance from either a splice site or the polyadenylation site, and long 3'-untranslated regions can trigger mRNA decay....

Palmieri et al. (1) cloned and sequenced a cDNA fragment encoding bovine seminal ribonuclease (RNase BS 1) from amino acid residue 47 up to the C-terminal residue. The characterized clone p17G3 in addition to the partial coding sequence contained the complete 3'-untranslated region. On screening a cDNA library from bovine seminal vesicle tissue by colony hybridisation employing synthetic primer...

Deployment of the bicoid morphogen gradient in early Drosophila embryos requires the prelocalization of bicoid mRNA to the anterior pole of the egg. This anterior localization is mediated by a cis-acting localization signal contained within the 3' untranslated region of the bicoid mRNA. Here we use a series of bicoid transgenes carrying small deletions in the 3' untranslated region to survey fo...

Plasmids p749, p106, and p150 contain cDNA inserts complementary to rat skeletal muscle actin mRNA. Nucleotide sequence analysis indicates the following sequence relationships: p749 specifies codons 171 to 360; p150 specifies codons 357 to 374 together with 120 nucleotides of the 3'-non-translated region; p106 specifies the last actin amino acid codon, the termination codon and the entire 3' no...