Lichen planus (LP) is a papulosquamous dermatosis that involves the skin, scalp, nails and mucous membranes. Although its pathogenesis is still unknown, there is evidence that an imbalance of immunologic cellular reactivity plays an important role. Histopathologic examination reveals characteristic interface dermatitis. Dermoscopy is a non-invasive tool, useful in the assessment of inflammatory...

Subungual melanoma with pigmentation beneath the nail that extends to involve the proximal nail fold is referred to as Hutchinson's sign. Black or brown subungual discoloration involving the proximal nail fold secondary to other etiologies has been referred to as pseudo-Hutchinson's sign. Three patients with nail discoloration and concurrent dyschromia of the proximal nail fold are described: a...

Nevus of Ota (nevus fuscoceruleus ophthalmomaxillaris) is a benign dermal melanocytic hematoma clinically appearing as a bluish-brown discoloration in the ophthalmic and/or maxillary branches of the trigeminal nerve. The condition first described by Ota and Tanino occurs predominantly in Asians with estimated frequency of 0.014% to 0.034%, but can be found in other ethnicities. Historical thera...

BACKGROUND Previous laser treatments for Poikiloderma of Civatte (PC) (i.e., Pulsed dye, Intense Pulsed Light, KTP and Argon) are limited by side effect profiles and/or efficacy. Given the high degree of safety and efficacy of ablative fractional photothermolysis (AFP) for photoaging, we set out to assess the efficacy of PC with AFP. DESIGN A prospective pilot study for PC in 10 subjects with...

Dromaeosaurid theropod dinosaurs, such as Velociraptor, possess strongly recurved, hypertrophied and hyperextensible ungual claws on the pes (digit II) and manus. The morphology of these unguals has been linked to the capture and despatching of prey. However, the mechanical properties or, more importantly, the mechanical potential of these structures have not been explored. Generation of a 3D f...

angiofibromas.4 Successful treatment of nonangiofibroma cutaneous manifestations of TSC has been sparse. To our knowledge, topical rapamycin has not been used successfully to treat the ungual fibromas of TSC. In our case, the use of topical rapamycin was well tolerated and resulted in the resolution of subungual tumors and rapid normalization of the overlying nail distortion. The pathogenesis o...

n engl j med 367;23 nejm.org december 6, 2012 2240 A 40-year-old woman presented with a 3-month history of a painful subungual mass of the left thumb. Examination revealed a tender, keratotic, subungual nodule (Panel A). Radiography of the digit showed a welldefined, cup-shaped erosion of the distal phalanx corresponding to the overlying subungual nodule (Panels B and C; the scale bar in the le...

A 42-year-old male with long-standing lymphedema presented to discuss therapeutic options for increasing leg swelling. His lymphedema began spontaneously in his midteens and asymmetrically involved both legs. No family history of lymphedema existed. Physical examination was remarkable for minimally pitting bilateral lymphedema extending from the toes to the upper calves. His toenails were diffu...