The umbilical cord (UC) has recently been added to the list of potential cell sources for tissue engineering and regenerative medicine purposes. Although the UC is usually discarded after delivery, UC storage in special tissue banks is becoming an increasingly common procedure. Indeed, the capacity of UC cells to be directed toward different phenotypes makes this tissue an ideal cell source for...

Background: Mesenchymal stem cells (MSCs) are ideal cells for cell and gene therapy. However, the low survival of MSCs after transplantation has limited their applications. We aimed to evaluate the expression of cytoprotective genes including NQO1, TXNRD1, HO-1, GCLC following the over expression of Nrf2 in umbilical cord-derived MSCs (UC-MSCs). Methods: 3-5 passages of UC-MSCs were cultured. ...

Disorders of the esophagus could include various conditions such as inflammation, stricture or esophageal-phase dysphagia. Management these disorders is rapidly developing, which includes conservative, surgical and modern techniques use stem cells. Stem cells are characterized have not differentiated, able to multiply differentiate into multiple organ cells, has ability self-renewal vital in di...

Background: Ulcerative colitis (UC) is an autoimmune inflammatory bowel disease, characterized by chronic and relapsing inflammation of the intestinal mucosa. Clinical treatments fail to reduce induce side effects in nearly 30% patients. Mesenchymal stem cells (MSCs) are immunomodulatory agents that can encourage tissue repair regeneration.
 Aim: To investigate ability MSCs differentiate i...

Objective(s) Human umbilical cord blood (HUCB) is now considered as a valuable source for stem cell–based therapies. Previous studies showed that intravascular injection of the HUCB significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). In the present study, we hypothesize transplanted HUCB derived mononuclear cells (UC-MCs) can decrease injur...

BACKGROUND AND OBJECTIVES Adult bone marrow (BM) is the major source of mesenchymal stem cells (MSC) for cell therapy. However, aspiration of BM involves invasive procedures. We isolated MSC from human full term umbilical cord tissues (UC). The biological characteristics of MSC derived from UC (UC-MSC) were further determined and compared with normal adult bone marrow-derived MSC (BM-MSC). DE...

Stem cell therapy is a powerful technique for the treatment of a number of diseases. Stem cells are derived from different tissue sources, the most important of which are the bone marrow (BM), umbilical cord (UC) blood and liver. Human UC mesenchymal stem cells (hUC-MSCs) are multipotent, non-hematopoietic stem cells that have the ability to self-renew and differentiate into other cells and tis...

Abstract Background A long-term of peritoneal dialysis (PD) using a hypertonic PD solution (PDS) leads to patient’s membrane (PM) injury, resulting in ultrafiltration failure (UFF) and drop-out. Our previous study shows that effluent-derived mesenchymal stromal cells (pMSCs) prevent the PM injury normal rats after repeated exposure cavity PDS. This was designed compare cytoprotection between pM...

Transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for repair of traumatic brain injury has been used in the clinic. Hyperbaric oxygen (HBO) treatment has long been widely used as an adjunctive therapy for treating traumatic brain injury. UC-MSC transplantation combined with HBO treatment is expected to yield better therapeutic effects on traumatic brain injury. In this ...