BACKGROUND Prostaglandin E which is present abundantly in the gastric mucosa is a powerful inhibitor of gastric acid secretion and a stimulus to gastric mucus production. In addition, prostaglandin E2 inhibits ulcer formation in animals, and the synthetic analogues of prostaglandin E have successfully been used in the treatment of patients with gastric and duodenal ulcer disease. To evaluate th...

Although various markers have been used in attempts to elucidate the mode of inheritance of duodenal ulcer, they have not significantly contributed to a clear understanding of the problem. In the present study total serum pepsinogen was used as a genetic marker and its concentrations were estimated in 100 ulcer patients and their family members up to three generations. Eighty three per cent of ...

Previous studies have suggested that patients operated upon for duodenal ulcer who have a previous history of perforation or haemorrhage are particularly liable to haemorrhage after operation from a proved or probable stomal ulcer (Langman, 1965). The cause of this association is unknown but there is evidence that patients of blood group 0 are particularly prone to duodenal ulcer haemorrhage (L...

Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally in...

Prevalence of helicobacter pylori was evaluated by urease test in 513 patients undergoing GI endoscopy, in hospital No1 Kerman university of medical sciences and health services from June 1992 through April 1993. H. Pylori was detected in 56.9℅ of tested samples by urease test. There was no significant correlation with sex, age and cigarette smoking. Prevalence of H.pylori was 16℅ in control gr...

gastric ulcer is one of the most prevalent gastrointestinal (gi) disorders, which affects approximately 5-10% of people during their life. in recent years, plentiful works have been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. tripleuro-spermum disciforme is one of the indigenous plants that is readily available and has been tradi...

Stomal Ulceration Stomal ulceration may follow anastomosis of the stomach to any other part of the alimentary canal. I have indicated in my first lecture that by I954, stomal ulceration had followed in over 50 per cent. of the cases in which I had carried out a gastrojejunostomy for duodenal ulcer in I943. In such cases at the second operation, the duodenal ulcer, although often reported as act...

In Central Europe and in South Africa duodenal ulcer disease has been reported to occur twice as often in migrant workers as in the indigenous population. To investigate the reasons for this phenomenon the joint effect of occupation and nationality on the prevalence of gastric and duodenal ulcer was studied in a survey of 73,000 active members of the German workforce. Non-ulcer dyspepsia and ga...