The mouse T (Brachyury) gene is required for early mesodermal patterning. Mice homozygous for mutations in T die at midgestation and display defects in mesodermal tissues such as the notochord, the allantois and the somitic mesoderm. To examine the role of T in patterning of somitic and posterior mesoderm along the anterior-posterior axis, we have examined the expression of a panel of molecular...

Nach einer Einleitung und Diskussion tiber die Eingen­schaften der diabetischen Krankheiten wurde ausflihrlich trber die Aetiologie und Pathophysiologie der Zuckeran­kheiten,insbesondere der Altersdiabetis,gesprochen.Nach der symptomalogie der Diabetis haben wir die ncueste Einteilung der Zuckerkrankheiten genannt und die Untc­rsuchungsmethoden,die heute Uhlich sind,erwahnt;dazu wurden unsere M...

in the present work an attempt has been made to study the effect of the twisted tapes as bed internals, on the performance of the gas-solid fluidized beds. experimental investigation has been carried out in cylindrical column with and without twisted tapes. twelve numbers of twisted tapes of three different widths with four values of the twist ratios for each width were studied at different sta...

background: the aim of the present study was to evaluate how left ventricular twist and torsion are associated with sex between sex groups of the same age. materials and methods : twenty one healthy subjects were scanned in left ventricle basal and apical short axis views to run the block matching algorithm; instantaneous changes in the base and apex rotation angels were estimated by this algor...

conclusions lv twist, torsion and untwist and also rate of them are significantly impaired in dcm and this impairment is well-related to lv global systolic and diastolic dysfunction. vvi is a new noninvasive technique that can be used to evaluate lv torsional parameters. results lv twist value (5.54 ± 1.94° in dcm vs. 11.5 ± 2.45° in control group) and also lv torsion (0.71 ± 0.28°/cm in dcm vs...

The transcription factor Twist plays vital roles during embryonic development through regulating/controlling cell migration. However, postnatally, in normal physiological settings, Twist is either not expressed or inactivated. Increasing evidence shows a strong correlation between Twist reactivation and both cancer progression and malignancy, where the transcriptional activities of Twist suppor...

Wnt1, initially identified as a mammary oncogene, can activate transcription via beta-catenin/TCF complexes. Twist, a transcription factor of the basic helix-loop-helix class, has also been suggested to have oncogenic properties. The aim of this study was to determine whether Twist is regulated by Wnt1 and might thus be a novel mediator of Wnt signaling. We found that Twist was up-regulated in ...

Wnt1, initially identified as a mammary oncogene, can activate transcription via -catenin/TCF complexes. Twist, a transcription factor of the basic helix-loop-helix class, has also been suggested to have oncogenic properties. The aim of this study was to determine whether Twist is regulated by Wnt1 and might thus be a novel mediator of Wnt signaling. We found that Twist was up-regulated in C57M...

TWIST, a basic helix-loop-helix (bHLH) transcription factor that regulates mesodermal development, has been shown to promote tumor cell metastasis and to enhance survival in response to cytotoxic stress. Our analysis of rat C6 glioma cell-derived cDNA revealed TWIST expression, suggesting that the gene may play a role in the genesis and physiology of primary brain tumors. To further delineate a...

Altered expression of Twist, matrix metalloproteinase (MMP)-2 and MMP-9 proteins has been identified in various types of human cancers. However, the correlation between Twist and these gelatinases in breast cancer remains unclear. In this study, immunohistochemical analysis of Twist, MMP-2 and MMP-9 expression was performed on tissue microarrays from 200 breast cancer cases. The association of ...