Background: Tumor associated antigens can be viably used to enhance host immune response. Objectives: The immunomodulatory effect of biogenic selenium nanoparticles (SeNPs) was compared between treated and untreated mice with crude antigens of 4T1 cells. Materials and Methods: Female inbred BALB/c mice (60) were injected by cancinogenic 4T1 cells causing breast cancer. After 10 days, all tumor ...

this article reviews the recently published data on the diagnosis of cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development.  most of the tumor markers are proteins that either numerically increase in response to the alteration of cancer conditions or are produced by cancer cells. however, they are natural compounds o...

background: interleukin (il)-23 and il-27 are two il-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. il-12 and il-27 seem to have antagonistic roles with il-23 in tumor site. in this study, il-23 and il-27 mrna expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitativ...

introduction: as a physical treatment, electrochemical therapy (echt) has provided an effective and useful  approach  for  treating  localized  tumors.  the  chemical  changes  due  to  a  direct  electric  current  destroy  the  tumor. this study evaluates the effect of electrical dose and polarity on the efficacy of the treatment of a  colon tumor model.  materials and methods: in order to in...

Background: Noradrenaline (NA), the principal neurotransmitter released from sympathetic nerve terminals, influences T-cell maturation, not only directly in developing T cells, but also indirectly, by acting on the thymic nonlymphoid cells. In vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, antiangiogenic and cytotoxic properties of propranolol, β-AR blocker,...

Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was ...

conclusions most patients are referred for restaging and demonstrate evidence of regional or distant metastasis with significant value for further treatment planning. providing insurance coverage and familiarizing referring physicians about appropriate indications of this relatively new diagnostic modality will be to the best interest of head and neck cancer patients in long term. methods we re...

objectives: multidrug resistance (mdr), which may be due to the over expression of p-glycoprotein (pgp) and/or mrp, is a major problem in neoadjuvant chemotherapy of osteosarcoma. the aim of this study was to investigate the role of tc-99m mibi scan for predicting the response to pre-operative chemotherapy. materials and methods: twenty-five patients (12 males and 13 females, aged between 8 and...

background: gbm is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. several researchers around the world, including iran, have been investigated gbm-cell line in vitro. however in vivo studies have not been fulfilled. methods : as standard cell line (u-87mg) derived from human gbm and total gbm tumor derived from...

Objective(s): Breast cancer is one of the most common cancers in the world and is on the increase. MUC1 and HER2 as tumor-associated antigens (TAAs) are abnormally expressed to some extent in 75–80% of breast cancers.  In our present research, a novel chimeric MUC1-HER2 (HM) protein was designed and used to study whether an immune response can be generated against these TAAs. In vitro analysis ...