We studied the feasibility of evaluating tumor control probability (TCP) reductions for tumor motion beyond planned gated radiotherapy margins. Tumor motion was determined from cone-beam CT projections acquired for patient setup, intrafraction respiratory traces, and 4D CTs for five non-small cell lung cancer (NSCLC) patients treated with gated radiotherapy. Tumors were subdivided into 1 mm sec...

Target motion-induced uncertainty in particle therapy is more complicated than that in X-ray therapy, requiring more accurate motion management. Therefore, a hybrid motion-tracking system that can track internal tumor motion and as well as an external surrogate of tumor motion was developed. Recently, many correlation tests between internal and external markers in X-ray therapy have been develo...

King’s College London, Division of Imaging Sciences and Biomedical Engineering, London, UK The impact of respiratory motion correction on quantitative accuracy in PET imaging is evaluated using real-time simulations for variable patient specific characteristics such as tumor malignancy and respiratory pattern. Respiratory patterns from real patients were acquired, with long quiescent motion per...

Successful radiotherapy treatment depends heavily upon the accuracy of patient geometry captured during treatment simulation using computed tomography (CT) scans. Radiotherapy patients are often scanned under free breathing, and respiratory motion can cause severe artifacts in CT scans, including shortening, elongation or splitting of the shapes and shifting of the midpoint positions of the tum...

Conventional evaluations of tumor tracking algorithms require inter-observer segmentations from radiation oncologists on the Cine-MRI (2D sagittal MR video). Instead performing intensive manual annotations images, we present a 2D video simulator that uses pre-treatment including breathing model, generates Cine-MR images in parallel with underlined segmentation tumor. We include data seven patie...

PURPOSE The treatment of moving targets with intensity-modulated radiotherapy may introduce errors in dose delivery. The motion of tumors in the abdomen was studied using quantitative fluoroscopic analysis, and the effect on dose delivery to the target was studied. METHODS AND MATERIALS Fluoroscopy sessions for 7 patients with pancreas or liver tumors and fiducial clips were recorded, convert...

abstract  background: resection of the distal end of the radius is indicated in the treatment  of locally aggressive primary benign and malignant bone tumors. the aim of this study  was to evaluate the technique of osteoarticular allograft reconstruction of the distal radius after wide excision of a giant-cell tumor.  methods: we analyzed 15 patients retrospectively who had reconstruction of th...

Tumor motion during radiation treatment on a helical tomotherapy unit may create problems due to interplay with motion of the multileaf collimator, gantry rotation, and patient couch translation through the gantry. This study evaluated this interplay effect for typical clinical parameters using a cylindrical phantom consisting of 1386 diode detectors placed on a respiratory motion platform. All...