High-grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell-like capacity. The stem-like cells maybe the cells of origin for tumor relapse. However, the tumor-associated parenchymal cells such as vascula...

Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have be...

Persistent JAK-STAT3 signaling is implicated in many aspects of tumorigenesis. Apart from its tumor-intrinsic effects, STAT3 also exerts tumor-extrinsic effects, supporting tumor survival and metastasis. These involve the regulation of paracrine cytokine signaling, alterations in metastatic sites rendering these permissive for the growth of cancer cells and subversion of host immune responses t...

Introduction: Introduction: Molecular components within the microenvironment act upon cell growth, survival/apoptosis, and proliferation. Immune system cells respond to molecules produced by the tumor and released in the surrounding microenvironment, such as cytokines, chemokines, and growth factors. This study aimed to identify the effects of tumor environment on monocyte-macrophage cell linea...

The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...].

A number of authoritative reviews devoted to the role of the tumor microenvironment have been published in recent years [1,2]. It is evident that the tumor stroma can modulate many tumor characteristics including the response to therapy. We need to keep this in mind, especially now that there is an increasing tendency to base intervention strategies on the driver mutations present in the tumor ...

In article number 2007051, Shuo Shi, Chunyan Dong, and co-workers present a stimuli-responsive multifunctional anti-tumor nanoplatform. Its photothermal effect ablates local tumor cells while strengthening infiltration of T lymphocytes. The released AUNP-12 PQ912 remarkably relieve both the innate adaptive immunosuppression in microenvironment. synergized dual immune checkpoint blockading thera...

The tumor microenvironment is a mixture of extracellular matrix molecules, tumor cells, endothelial cells, fibroblasts and immune cells. Tumor growth and metastasis formation are dependent on the growth of blood vessels into the tumor mass. The tumor microenvironment contributes to this pathological angiogenic process. The extracellular matrix and basement membranes are a source for endogenous ...

Purpose: There is increasing evidence for the importance of tumor oxygenation in the development, progression, and response to therapy. Consequently, many techniques have been developed to assess tumor oxygenation, as reviewed extensively . Methods may provide a qualitative impression of oxygenation status or rigorous quantitation. Techniques vary in spatial and temporal resolution and the abil...

Cancers are heterogeneous tissues comprised of multiple components, including tumor cells and microenvironment cells. The tumor microenvironment has a critical role in tumor progression. The tumor microenvironment is comprised of various cell types, including fibroblasts, macrophages and immune cells, as well as extracellular matrix and various cytokines and growth factors. Fibroblasts are the ...