Objective To detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery. Methods We retrospectively reviewed 120 patients who underwent radical hysterectomy and pelvic lymphadenectomy as treatment for stage IB1 cervical cancer. Results Overall,...

BACKGROUND Neck metastasis is the most important prognostic factor in oral cavity squamous cell carcinomas (SCC). Apart from the T- stage, depth of invasion has been used as a highly predictable factor for microscopic neck metastasis, despite the controversy on the exact depth cut off point. Depth of invasion can be determined clinically and radio logically. However, there is no standard tool t...

Introduction: Light-driven cancer therapy strategies (e.g. photodynamic therapy and photothermal therapy) have undergone remarkable progress in recent years, but they still suffer from a serious drawback of limited penetration depth of light in tissue. As a non-invasive and non- ionizing radiation, ultrasound can be focused remotely, transferring acoustic energy deep in the bo...

introduction: secondary radiation such as photoelectrons, auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external x-ray beam after being loaded with elements capable of activating the tumor, e.g.; i and gd. materials and methods:  in this investigation, the mcnpx code was used for simulation and calculation of dose enhancement facto...

OBJECTIVE To assess the effects of tumor size, proximity to midline and invasion depth of oral cancer of the tongue (TC) on neck metastasis and recurrence. METHODS In this retrospective observational study, was conducted through a chart review of the 11 male and 9 female patients who underwent surgeries with the diagnosis of tongue squamous cell carcinoma and at least one side neck dissection...

Although endoscopic ultrasonography (EUS) is the first-choice imaging modality for predicting the invasion depth of early gastric cancer (EGC), the prediction accuracy of EUS is significantly decreased when EGC is combined with ulceration.The aim of present study was to compare the accuracy of EUS and conventional endoscopy (CE) for determining the depth of EGC. In addition, the various clinic-...

Background: To enhance the dose to tumor, the use of high atomic number elements has been proposed.Objective: The aim of this study is to investigate the effect of gold nanoparticle distribution on dose enhancement in tumor when the tumor is irradiated by typical monoenergetic X-ray beams by considering homogeneous and inhomogeneous distributions of gold nanoparticles (GNPs) in the tumor.Method...

background: intraoperative radiation therapy (iort) technique is used to treat a surgically exposed tumor or tumor bed in the treatment of locally advanced intraabdominal, retroperitoneal, pelvic, thoracic, breast and soft tissue tumors. one way to perform iort is to use an existing linac and modify the treatment head using an applicator system. in this study the objectives were to design, and ...

Cancer genomes exhibit profound somatic copy number alterations (SCNAs). Studying tumor SCNAs using massively parallel sequencing provides unprecedented resolution and meanwhile gives rise to new challenges in data analysis, complicated by tumor aneuploidy and heterogeneity as well as normal cell contamination. While the majority of read depth based methods utilize total sequencing depth alone ...