background: bone resorption is one of the main features of inflammatory periapical lesions and is mainly mediated by interleukin-1 beta (il-1β), tumor necrosis factoralpha (tnf-α) and prostaglandin-e2 (pge2). recent investigations of these lesions revealed that pharmacological modulation may be possible. objective: the aim of this study was to evaluate the effect of ibuprofen on il-1β, tnf-α an...

many species of tea (camellia sinensis) and cowslip (echium amoenum) are used in iranian traditional medicine. the aim of this study was to conduct the survey on the ability of iranian black tea and cowslip extracts on secretion of tumor necrosis factor-alpha (tnf-alpha) by non-infected and infected mouse macrophages. a macrophage infection model with legionella pneumophila and enzyme linked im...

background: the pro-inflammatory cytokine, tumor necrosis factor-alpha (tnf-α), is a pathogenic element for a number of disorders. previous studies have reported that the -1031 t/c and -238 g/a polymorphisms in the promoter region of the tnf-α gene are important factors in reproductive-related disorders. one of the most common gynecological diseases of women during the reproductive years is end...

crohn’s disease is an inflammatory bowel disease (ibd), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. environmental triggers and interaction of genetic determinants also play an indispensible role. in this case report, we present a pre-pubertal girl with intermittent and refra...

pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. alleles of the interleukin-l-beta (il-lβ) and tumor necrosis factor alpha (tnf-α) genes are associated with pr-eeclampsia in several studies in different popul...

conclusions according to our result, 1525g/a and 1595c/t were in strong linkage disequilibrium and the polymorphisms of the trail gene in the 3’ utr region were not associated with the outcome of hbv infection. results our data showed that genotypes 1525g/a and 1595c/t were in complete linkage disequilibrium and the genotype frequencies at the two positions were the same. no significant differe...

In this paper the performance of bagging in classification problems is theoretically analysed, using a framework developed in works by Tumer and Ghosh and extended by the authors. A bias-variance decomposition is derived, which relates the expected misclassification probability attained by linearly combining classifiers trained on N bootstrap replicates of a fixed training set to that attained ...