نتایج جستجو برای: trypanocidal activity
تعداد نتایج: 1134678 فیلتر نتایج به سال:
Due to limited efficacy and considerable toxicity, the therapy for Chagas' disease is far from being ideal, and thus new compounds are desirable. Diamidines and related compounds such as arylimidamides have promising trypanocidal activity against Trypanosoma cruzi. To better understand the mechanism of action of these heterocyclic cations, we investigated the kinetoplast DNA (kDNA) binding prop...
OBJECTIVES As part of a search for new therapeutic opportunities to treat chagasic patients, in vitro efficacy studies were performed to characterize the activity of five novel arylimidamides (AIAs) against Trypanosoma cruzi. METHODS The trypanocidal effect against T. cruzi was evaluated by light microscopy through the determination of IC₅₀ values. Cytotoxicity was determined by MTT assays ag...
The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S. lycocarpum fruit powders were submitted to exhaustively extraction with 96% ethanol and solamargine were isolated from the extract of S. palinacanthum. Both extracts and sol...
A multi-step cascade strategy using integrated ligand- and target-based virtual screening methods was developed to select a small number of compounds from the ZINC database to be evaluated for trypanocidal activity. Winnowing the database to 23 selected compounds, 12 non-covalent binding cruzain inhibitors with affinity values (K i) in the low micromolar range (3-60 µM) acting through a competi...
Trypanocidal Activity of Oil of the Young Leaves of Nepeta cataria L. Obtained by Solvent Extraction
Trypanocidal activity was found in the volatile oil of the Young leaves of Nepeta cataria L. which has been extracted by diethyl ether and analyzed by GC and GC/MS. Four compounds in the oil of N. cataria, representing 97.53% of the oil were identified. The oil was enriched of monoterpenes with α- citral (51.95%) as the major compound. Other main compounds were β- citronellol (9.03%), geraniol ...
The emergence of trypanocidal resistance has led to a change in the behavior and use local plants for treatment parasites. activity Strychnos spinosa aqueous ethanolic extracts on Trypanosoma brucei was evaluated during ten days treatment. Thus, smear used monitor parasitaemia mice treated with spinose by gavage at doses 250, 500, 1000 mg/kg (test groups); 10 ml/kg distilled water (negative con...
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