Background: Since alkaloids are nitrogenous compounds, the availability of nitrogen (N) is expected to play an important role in the biosynthesis and accumulation of alkaloids in plants. Objective: This study intended to investigate the nitrogen (N) fertilization and water deficit stress (WDS) effects on seed tropane alkaloids elicitation including hyoscyamine (HYO) and scopolamine (SCO), and ...

Tropane alkaloids, especially hyoscyamine (HYO) and scopolamine (SCO), are widely used in medicine for their antispasmodic, anticholinergic, and sedative properties. This study was undertaken to investigate the root and shoot tropane alkaloids production from in vitro shoot tip (as explant) culture of Hyoscyamus niger under different plant growth regulators including auxins (IAA, 2, 4-D, IBA, N...

Baogongteng A (BGT-A), a naturally occurring tropane muscarinic agonist isolated from Chinese medicinal plant, exhibits a bioactive effect different from those of many tropane alkaloids that are muscarinic antagonists. A series of racemic derivatives of BGT-A was synthesized to study the structure-activity relationships (SAR). To explore further the SAR in this series and to ultimately design m...

Brugmansia candida (Solanaceae) is a native tree distributed across South-American and produces the pharmacologicallyimportant group of tropane alkaloids including scopolamine. This biocompound is synthesised from hyoscyamine by action of Hyoscyamine 6-β hydroxylase (H6H, EC 1.14.11.11) at the end of the tropane alkaloid pathway. Here are reported the tissue and organ-specific expression of h6h...

Background: Black henbane with the scientific name of Hyoscyamus niger which has a wide geographic distribution, is considered as one the most important species for tropane alkaloids extraction. Objective: In this research, morphological and tropane alkaloids variations were assessed within different population of H. niger in their natural habitats. Methods: Totally, 56 individuals were colle...

Background & Aim: A. belladonna (family: Solanaceae) is one of important pharmaceutical plants which contain tropane ‎alkaloids. Tropane alkaloids are distinct group of secondary metabolites of the ‎Solanaceae family.  The most important alkaloids of A. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. There...

Fifty three alkaloids were identified in the organs (roots, stems, leaves, flowers, and seeds) of Datura innoxia by GC/MS. Seventeen of them are reported for the first time for this species and one nor-derivative, 3-phenylacetoxynortropane (28), for the genus Datura. Furthermore, four new tropane esters were tentatively identified as 3-acetoxy-6,7-epoxytropane (acetylscopine) (10), 3-acetoxy-6-...

The strict application of IUPAC rules for the numbering of tropane alkaloids is not always applied by authors and there is hence a lot of confusion in the literature. In most cases, the notation of 3, 6/7-disubstituted derivatives has been chosen arbitrarily, based on NMR and MS data, without taking into account the absolute configuration of these two carbons. This paper discusses the problem a...

background: since alkaloids are nitrogenous compounds, the availability of nitrogen (n) is expected to play an important role in the biosynthesis and accumulation of alkaloids in plants. objective: this study intended to investigate the nitrogen (n) fertilization and water deficit stress (wds) effects on seed tropane alkaloids elicitation including hyoscyamine (hyo) and scopolamine (sco), and a...