background: human cornea expresses functional fas-ligand capable of killing fas+ activated lymphocytes. fas expression is partly regulated by -670 a/g polymorphism in the promoter region of fas gene. objective: the aim of the present study is to determine the association between fas-670a/g polymorphism and survival of corneal transplantation. methods: in 276 graft recipients who mainly underwen...

the antidiuretic effect of arginine vasopressin (avp) is mediated by the vasopressin v2 receptor. the docking study of avp as a ligand to v2 receptor helps in identifying important amino acid residues that might be involved in avp binding for predicting the lowest free energy state of the protein complex. whereas previous researchers were not able to detect the exact site of the ligand-receptor...

Macrocyclic heterobinuclear Zn(II)–Cu(II) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. The ligands include similar N4O2 and dissimilar N(imine)3O2 and N(amine)3O2 coordination sites sharing two phenolic oxygen atoms. The six-coordination site comprises two pyridyl pendant arms on the amine nit...

A novel polyfunctional dipodal ligand, L = N,N'-bis[2-[(2-hydroxy-1-naphthyl)methyleneamino]ethyl]propanediamide (DOTA2HNAP) was developed and characterized through elemental and spectral analyses. The complexation behavior of the ligand was investigated with Co2+, Cu2+, and Zn2+ metal ions by potentiometric and spectrophotometric methods in H2O-D...

Siilver tetrafluoroborate complex of 5.11.17.23-tetra-tert-butyl-25-26,27,28-tetrakis (diphenylphosphinoylmethoxy)calyx[4]arene (L) has been synthesized by reaction of silver tetrafluoroborate and L in dichloromethane at room temperature. The complex formed has a 1:1 metall/ligand ratio. 1H and 31P NMR data support an encapsulated structure of the complex in which silv...

The Ni(II) and Zn(II) complexes with phenylpyridylformamidine (PhPyF) ligand, [Ni(PhPyF)Cl2] and [Zn(PhPyF)Cl2], have been prepared and investigated using different chemical techniques such as elemental analysis, molar conductance, FT-IR, UV-vis spectra and magnetic moment. The obtained chemical analysis data showed the formation of 1:1 (metal: ligand) ratio. The square planar and tetrahedral g...

calcification and inflammation are among the important cases of exudative age-related macular degeneration (e-armd). the aim of the present study was to elucidate if there is any relationship between serum osteoprotegerin (opg), soluble receptor activator of nuclear factor-kappa b ligand (rank-ligand) and e-armd. in a cross-sectional study, we compared 45 e-armd patients with 45 matched control...

a new series of transition metal complexes of co(ii), ni(ii), cu(ii) and zn(ii), has beensynthesized from the knoevenagel condensate schiff base ligand(l) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. structural features were determinedby spectral and analytical techniques. square-planar geometry has been adopted by thecomplexes except cobalt complex which ...

AChE is an enzyme that is predominate in a healthy brain, while BChE is considered to play a minor role in regulating the levels of ACh (memory molecule) in the brain. In addition to setting the ACh level, these two enzymes also facilitate Aβ aggregation by forming stable complexes and participate in the abnormal phosphorylation of the tau protein, which also contribute to the development of Al...