One-pot Fischer indolisation indole N-alkylation enables straightforward, rapid synthesis of structurally-diverse 1,2,3-trisubstituted indoles from simple, widely-available precursors.

C–H olefination of alkynes has been realized as an efficient approach to access axially chiral trisubstituted olefins, where two classes arenes have identified.

3- And 9-component Pd(0) catalysed assembly of allenes, aryl iodides and N-nucleophiles with concomitant installation of trisubstituted Z-alkenes is readily achieved.

The stereospecific and regioselective C(3) alkynylation of trisubstituted epoxides has been achieved with lithium alkynyl trimethylaluminium ate complexes in the presence of BF3 x OEt2.

A variety of 1,1,2-trisubstituted-1H-indenes are synthesized by the reaction of aliphatic ketones, aryl-substituted alkynes and NbCl3(DME) in 1,2-dichloroethane under reflux conditions.

The highly regioselective, stereospecific ring-opening of trisubstituted N-tosylaziridines possessing vinyl and hydroxymethyl groups by sulfone- and sulfide-stablised carbanions is reported.

Abstract In this study, the molecular dynamics simulation of imidazole-modified polyacrylamide (VPAM) and (PAM) system showed that VPAM containing had better cohesion-bonding effect than PAM without imidazole. Based on imidazole-containing system, cohesion properties functional monomers mechanism in process were analyzed at high temperature salt, structure-activity relationships between chemica...

Mono- and binuclear arene–ruthenium(II) complexes with imidazole-containing ligands were prepared by the reaction of (L1 = bis(imidazole-1-yl)methane; ImH 1H-Imidazole; BImH 1H-Benzimidazole) [(p-cym)Ru(µ-Cl)2]2 dimers. When bis(imidazole-1-yl)methane reacted in methanol, a complex type [Ru2(L1)2(p-cym)2Cl2]Cl2 (2) cyclic structure was synthesized, whereas using acetonitrile as solvent under sa...

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concent...