Abstract There has been a lively interest on macrocyclic polyamine alkaloids due to their remarkable pharmacological activities such as anti-tumor, anti-inflammatory, anti-Alzheimer's disease and anti-parasitic. Tripterygium wilfordii is widely used traditional Chinese medicine, which abundant in including alkaloids. However, there are rarely studies spermidine of T. so far. In this article, we...

Purpose Resistance to cancer chemotherapy is a major problem. Herb-drug combinations can offer a new potential to overcome such resistance. To quantitatively assess chemosensitizing effects of herb-drug combinations (HDC), a new approach that takes into account both the chemosensitizing effect (CE) and “safety” considerations of the HDC is proposed and used in describing the cytotoxic activity ...

Inflammatory diseases such as rheumatoid arthritis (RA) can lead to chronic pain and joint deformity. First line treatment includes disease-modifying antirheumatic drugs (DMARDs) slow disease progression, but RA patients are often left with debilitating symptoms. This article explores alternative topical naturally based options treat symptoms, supporting evidence for their use. Considered inclu...