We report a female patient who repeatedly developed pancreatitis after trimethoprim-sulfamethoxazole (TMP/SMX) use. During childhood she had undergone an ureterosigmoidostomy after which she had been on TMP/SMX 480 mg daily as prophylaxis for pyelonephritis for many years. The patient presented with abdominal pain caused by acute pancreatitis. No other cause, except for TMP/SMX use, could be id...

clinical strains and transformants had bands of β-lactamase activity with an alkaline pI of 7.6 and 5.4. Polymerase chain reaction (PCR) amplification of the 26 clinical isolates was positive for blaCTX-M and blaTEM (7). The 26 strains of E. coli had the same profile by repetitive-element PCR and pulsed-field gel electrophoresis, while unrelated control strains had very different profiles. Sequ...

TO THE EDITOR—Pneumocystis jirovecii is responsible for severe inflammatory pneumonia in transplant recipients [1–6]. We encountered a cluster of fulminant P. jirovecii pneumonia (PJP) in 14 transplant recipients occurring a mean of 6.3 years (SD, 5.3 years) after transplant, beyond our 6-month trimethoprimsulfamethoxazole (TMP-SMZ) prophylaxis period [4]. Additional clusters emerged in 7 other...

Klebsiella pneumoniae has emerged as the leading cause of community-acquired pyogenic liver abscess in many countries. Community-acquired pyogenic liver abscess due to K. pneumoniae with a unique antibiogram indicative of resistance only to ampicillin has been demonstrated. We reported the first case on community-acquired pyogenic liver abscess caused by CTX-M-15-type extended-spectrum -lactama...

Antibiotic therapy can affect not only the pathogenic bacteria, but also commensal microorganisms in the gut flora of humans, which might serve as a reservoir of antimicrobial resistance genes. Escherichia coli can be found widely in nature, and can also be implicated in human infectious diseases. Therefore, fecal E. coli is often considered as a good indicator for selection pressure imposed by...

To date, Eikenella corrodens, a fastidious, gram-negative rod, has not been recognized as a causative agent of urinary tract infections. Until now the organism has been isolated from infective endocarditis, abdominal, joint, and bone infections (3, 7), human bite wounds (9), genital ulcers after traumatic orogenital contact (5, 6), and other sites (3, 7, 10). E. corrodens is part of the human o...

Vol. 7, No. 3 Supplement, June 2001 Emerging Infectious Diseases 541 Henry Masur, from the National Institutes of Health, Bethesda, Maryland, discussed the changing nature of opportunistic infections (OIs) in HIV-infected persons in the United States in light of the use of highly active antiretroviral therapy (HAART). While the incidence of nearly all OIs has decreased since 1996, several AIDS-...

Among Gram-negative biodefence pathogens, Yersinia pestis (plague), Francisella tularensis (tularemia) and, to a lesser extent, Brucella species (brucellosis) are most widely studied. In contrast, Burkholderia mallei (glanders) and B. pseudomallei (melioidosis) have garnered less attention. While the underlying reasons are multifaceted, for example, perceived importance of an organism being lis...

In this study, molecular characterization of antimicrobial resistance of 116 Yersinia ruckeri strains isolated from rainbow trout (Oncorhynchus mykiss) with enteric redmouth disease (ERM) in commercial fish farms in the Northern and Eastern regions of Turkey was performed. The putative Y. ruckeri strains isolated were confirmed by PCR assays specific to the 16S rRNA gene of bacterium Y. ruckeri...

A retrospective study of the patterns of antimicrobial susceptibility and phage types of 111 Salmonella typhi strains isolated in 1996 from Vietnam was carried out. The strains were tested for susceptibility to chloramphenicol, ampicillin, tetracycline, trimethoprimsulfamethoxazole, nalidixic acid, ceftazidime, ceftriaxone and ciprofloxacin. Simultaneous resistance to chloramphenicol, ampicilli...