Interaction between the tricyclic antidepressant desipramine and the antihypertensive agent clonidine has been investigated in five hypertensive patients in a double-blind placebo controlled study. Introduction of the tricyclic antidepressant led to loss of blood pressure control in four of the patients. The average blood pressure rise in the desipramine period compared with the placebo period ...

This study is the first quantitative synchrotron grazing incidence X-ray scattering investigation of nanoscale film morphologies tricyclic block copolymers based on poly(n-decyl glycidyl ether) ...

An oxidative NHC-catalyzed synthesis of tricyclic dihydropyranones with three contiguous stereocenters has been developed. Studies the mechanism suggest that rate-determining step is Breslow intermediate formation.

Several investigators have recently developed guidelines for determining which patients with tricyclic antidepressant overdose should be hospitalized. The width of the QRS complex on the ECG and several clinical parameters have been proposed to identify patients at risk for major complications. To validate these, we developed an algorithm and then applied it to 45 patients who had overdosed on ...

The tricyclic antidepressants, while older, still have their place in the treatment of depression today. They are efficacious but less selective and thus have the potential of eliciting many side effects. Anticholinergic delirium is a potential complication when using a tricyclic antidepressant or other anticholinergic agent. Following the Naranjo algorithm, this case report describes a probabl...

Poisoning with tricyclic antidepressants is an important cause of drug-related self-poisoning in the developed world and a very common cause of poisoning and mortality in developing countries. Electrocardiographic manifestations of most tricyclic antidepressant-poisoned patients resolve by the administration of 1-2 mEq/kg of sodium bicarbonate. Some rare cases have been reported who have been r...