نتایج جستجو برای: tricarboxylic acid cycle

تعداد نتایج: 999374  

Journal: :Life 2021

The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins. In eukaryotic system, TCA occurs completely mitochondria, while intermediates are retained inside mitochondria due their polarity hydrophilicity. Under cell stress conditions, can become d...

Journal: :The Journal of biological chemistry 1991
K Y Tserng S J Jin

The metabolic conversion of dicarboxylic acids into succinate and other gluconeogenic intermediates in rat liver homogenates was investigated using [1,2,4-13C4]dodecanedioic acid as tracer. Isotope enrichments in 3-hydroxybutyrate, succinate, fumarate, and malate, as well as dicarboxylates (dodecanedioic, sebacic, suberic, and adipic acids) were measured with selected ion monitoring capillary c...

Journal: :The Journal of biological chemistry 1961
H E FIRSCHEIN J BELL

In a previous publication (1) the significance of lactic and citric acid synthesis by bone was discussed. Acid formation by other connective tissues such as cartilage (2, 3) cornea (4), and lens (5-7) has also been demonstrated. The presence of the glycolytic enzymes in skin and the formation of lactic acid have been demonstrated by several investigators (8-12). Although Dickens (13) found that...

Journal: :The Biochemical journal 2006
Natasha Hausler Jeffrey Browning Matthew Merritt Charles Storey Angela Milde F Mark H Jeffrey A Dean Sherry Craig R Malloy Shawn C Burgess

A great deal is known about hepatic glucose production and its response to a variety of factors such as redox state, substrate supply and hormonal control, but the effects of these parameters on the flux through biochemical pathways which integrate to control glucose production are less clear. A combination of 13C and [2H]water tracers and NMR isotopomer analysis were used to investigate metabo...

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