Imidazoles and their derivatives are compounds with chemotherapeutic applications. In this study, we investigated the chemical functionalization of carboxylated multiwalled carbon nanotubes (MWNT-COOH) by 1,2-phenylendiamine. Multiwalled nanotube (MWNT)-benzimidazole was obtained by an MWNT-amide reaction with POCl(3) after 72 hours, which was confirmed by Fourier transform infrared, scanning e...

In the presence of allyl tri-n-butyltin--AIBN, cyclopropylmethyl bromides/xanthates undergo ring-opening reaction with concomitant formation of geminal diallyl derivatives in good yields. The ring closing metathesis reactions on geminal diallyl derivatives with Grubbs' catalyst provided spirocyclopentenyl products. Combination of these two methodologies has been applied to the synthesis of mono...

Nitrogen containing heterocyclic compounds have great utility in synthetic, medicinal and material chemistry. Oxazole, isoxazole, thiazole, imidazole their derivatives gained prominence as they constitute the structural features of many bioactive compounds. In fact, amide functionality represents a privileged scaffold biomolecules drugs. The combination two or more heterocycles linked by into o...

The polysaccharide exuded by Acacia decurrens trees contains residues of D-galactose , LArabinose , L-Fucose and Dglucuronic acid. An examination of the OMethyl derivatives of the gum yields 2,3,4,6 tetra –O-methyl –D-galactose, 2,3 –di-O-Methyl –L-arabinose , 2,3,4-triO-methyl-D-galactose, 2,4-di-O-methyl-D-galactose together with 2,3,4 tri-O-methyl-Dglucuronic acid by acid hydrolysis. The deg...

A series of new dicarboxylic acid derivatives of 1,3,4-thiadiazines, 1,4-benzopiperizines, 1,4-thiazines, 1,3-thiazoles, 1,3-oxazoles and 1,3-imidazoles have been synthesized in 80-87% yield by the environmentally benign microwave induced technique involving the cyclocondensation of 2,3-dibromosuccinic acid with 2-aminothiophenol, o-phenylene diamine, 1,2,4-triazole, amidinothiocarbamide, amidi...

Methods Miss H.B, 30 years old, with a history of a psoriasis in the father. The patient was followed up for two years for a histologically confirmed sebopsoriasis. She received various therapies, initially put on moisturizers and Imidazoles but with no improvement, then on dermocorticoids and vitamin D derivatives. Treatment with UVB phototherapy could not be achieved, given the professional c...

Starting from commercially available amines and propargylamides a variety of substituted imidazoles were synthesized via a novel hydroamination-cyclization sequence. The target compounds are obtained in good to excellent yields in the presence of catalytic amounts of zinc triflate.