conclusions both l-prp and l-prf could be used to effectively promote the healing of articular cartilage defects of the knee. results mean macroscopic scores of the treated defects were higher than the controls at all sampling times with significant differences (p < 0.05) observed between l-prf treated and control defects (10.13 vs. 8.37) and l-prp treated and control defects (10 vs. 8.5) at 4 ...

the present experiment was designed to access the effects of methylmercury chloride ( mehgcl) on antioxidant status, protein concentration, lipid peroxidation and hydroperoxidation in brain parts, spinal cord, lung, heart and pancreas of rats. twenty male wistar rats (3 months old) were divided in saline controls (c) and mehgcl-treated group (mmc). treated rats were intoxicated with mmc at a do...

Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, inability to sit without support, and deficient levels survival motor neuron (SMN) protein. Risdiplam orally administered small molecule that modifies SMN2 pre–messenger RNA splicing increases functional SMN protein in blood.

Angiotensin II is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. Since vascular reactivity to angiotensin II changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...

Surveys were conducted in malaria-endemic villages in the southern province of Attapeu, Lao PDR during various seasons over a 3-year period. All-night mosquito landing collections, blood surveys and a case-control study were conducted. Plasmodium falciparum was the predominant species, and slide positivity rates were higher during the transition/dry season compared with the wet season. Anophele...

osteonecrosis (on) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. corticoid-induced on in rats and lipopolysaccharide (lps)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. d-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the ...

background: we compared bone mineral density (bmd) in patients with relapsing-remitting multiple sclerosis (rrms) on interferon with that of patients with relapsing-remitting multiple sclerosis (rrms) who were not receiving interferon and healthy age- and sex-matched controls. methods: overall, 30 patients with rrms on interferon (treated patients), 30 patients with rrms but not receiving inter...

Objective: Lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. Zingiber officinale Roscoe (ginger) possesses antioxidant properties. In present research, the effect ofhydroalcoholic extract of ginger (HEG) on the liver of lamotrigine-treated epileptic rats was investigated Material and Methods: Forty-eight female W...

This paper examines grandparents’ written accounts of conversations with their college-aged grandchildren. Using a thematic analysis, we describe 4 themes that indicate the place of the relationship in the grandparents’ lives and their general orientation to their grandchildren. It is argued that expressions of affiliation, pride, exchange (primarily of advice and information), and feeling dist...