OBJECTIVE To investigate the influence of decreased mechanical loading on the density and mechanical properties of the cancellous bone of the human mandibular condyle. DESIGN Destructive compressive mechanical tests were performed on cancellous bone specimens.Background. Reduced masticatory function in edentate people leads to a reduction of forces acting on the mandible. As bone reacts to it...

Nitric oxide (NO) is synthesized in normal muscle fibers by the neuronal (nNOS) and the endothelial (ecNOS) isoforms of nitric oxide synthase (NOS). NO contributes to the regulation of several processes such as excitation-contraction coupling and mitochondrial respiration. We assessed in this study whether NO production is regulated in response to an acute increase in muscle activation. Three g...

Strengthening the fundamental understanding of micromechanical methods in continuity is a critical aspect developing and designing future composite systems. Virtual testing has provided additional behavior materials on microstructural scale. However, experiments must be executed to determine their validity. Modeling realistic microstructures under loading conditions could help develop physicall...