Accelerated coronary atherosclerosis in cardiac allografts is the major limiting factor for long-term survival after heart transplantation. There is growing evidence that activation of the coagulation mechanism is involved in the development of transplant atherosclerosis. Tissue factor (TF) expression by cells of the monocyte/macrophage system may represent an important mechanism underlying the...

The aim of this study was to investigate the effects humic acid (HA) applications on rapeseed (Brassica napus L.) growth, heavy metal uptake, bioconcentration factor (BCF), translocation (TF), tolerance index (TI), catalase (CAT), ascorbate peroxidase (APX) enzyme activities and hydrogen peroxide (H2O2) content in polluted soil with lead (Pb), chromium (Cr), cadmium (Cd), zinc (Zn). Three doses...

Wetland macrophytes have advantages when used in the remediation of cadmium (Cd)-contaminated paddy fields because they can adapt to overly wet soil environments; however, only a few studies tested efficiency Cd phytoremediation. In this study, we investigated effect pH (pHs 5, 6, and 7) on accumulation translocation by Polygonum hydropiper (L.) low moderately Cd-contaminated (0.56 0.92 mg/kg, ...

Steel factor (SLF) acts synergistically with various hematopoietic growth factors that use the Jak-Stat pathways in vivo and in vitro, although the contribution by SLF to this pathway is unknown. We show here that SLF induces time- and dose-dependent phosphorylation of Stat3 in the human growth factor-dependent cell lines MO7e and TF-1. This phosphorylation occurs exclusively on serine residues...

A majority of tissue factor (TF) on cell surfaces exists in an encrypted state with minimal to no procoagulant activity. At present, it is unclear whether limited availability of phosphatidylserine (PS) and/or a specific membrane lipid in the outer leaflet of the plasma membrane contributes to TF encryption. Sphingomyelin (SM) is a major phospholipid in the outer leaflet, and SM metabolism is s...

OBJECTIVE The withdrawal of 3-hydroxy-3-methylglutaryl-coenzyme A-reductase inhibitors (statins) deteriorates endothelial function. We determined in vascular smooth muscle cells whether statin withdrawal leads to the expression of proinflammatory genes involved in the development and progression of arteriosclerosis. METHODS AND RESULTS The withdrawal of cerivastatin from pretreated vascular s...

The concentration of heavy metals (HMs) in soil-plant systems was an important indicator soil metal pollution, and the migration transportation abilities HMs from to plants were great significance for evaluating food safety reducing health risks. This study conducted investigate contamination translocation soil-Paeonia lactiflora system Bozhou, Anhui Province, China. pollution assessed by calcu...

Transcription factor (TF)-DNA interactions are the primary control point in regulation of gene expression. Characterization of these interactions is essential for understanding genetic regulation of biological systems and developing novel therapies to treat cellular malfunctions. Solid-state nanopores are a highly versatile class of single-molecule sensors that can provide rich information abou...

OBJECTIVE Oxidative stress contributes to the pathogenesis of many diseases, including atherosclerosis and sepsis. We have previously described a novel class of therapeutic compounds with antioxidant and antiinflammatory properties. However, at present, the intracellular targets of these compounds have not been identified. The purpose of this study was to elucidate the mechanism by which 2 stru...

treatment of soils contaminated with heavy metals using plant species is a method which has been widely used in thepast. this method, which is known as phytoremediation, has been applied for pollution treatment using different plantspecies worldwide. the method has been used for remediation of various types of pollutants in laboratory, pilot andindustrial scales. the aim of this study was to co...