With over 110,000 patients waiting for organ transplantation, the current crisis in organ transplantation is based on a lack of donors after brain-death (DBD). A very large alternative pool of donor organs that remain untapped are the donors after cardiac death (DCD), recovered after cardiac activity has ceased and therefore sustained some ischemic injury. Machine perfusion has been proposed as...

Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities against the injury incurred by ischaemia and reperfusion. It describes the intriguing phenomenon in which transient non-lethal ischaemia and reperfusion of one organ or tissue confers resistance to a subsequent episode of lethal ischaemia reperfusion injury in a remote orga...

brain death is defined as the permanent, irreversible and concurrent loss of all brain and brain stem functions. brain death diagnosis is based on clinical criteria and it is not routine to use paraclinical studies. in some countries, electroencephalogram (eeg) is performed in all patients for the determination of brain death while there is some skepticism in relying on eeg as a confirmatory te...

conclusions hcv coinfection, older age and ast were associated with lf in patients with hiv infection. objectives the aim of this cross-sectional study was to identify factors associated with liver fibrosis (lf) in patients with hiv monoinfection and hiv-hcv coinfection. patients and methods we analyzed lf by transient elastometry ([te], fibroscan) in three groups of patients (hiv, hiv-hcv and ...

Abstract The aim of the present study was to establish a novel method for inducing deep hypothermia in rats. Cooling rats anesthetized with isoflurane caused time-dependent decrease rectal temperature, but cardiac arrest occurred before their body temperature reached 20 °C when inhalation continued during cooling process. Stopping 22.5 successfully induced hypothermia, although stopping at 27.5...

conclusions this study shows that an adequate nutritional support, in patients with severe burn injury, can improve sofa score. it is also more cost-effective, resulting in a shorter los in hospital. background severe burned patients developed metabolic imbalances and systemic inflammatory response syndrome (sirs), which can lead to malnutrition, impaired immunologic response, multiple organ fa...

BACKGROUND There is an ever-increasing demand for cadaveric solid organs for transplantation all over the world. Partial strategies in many countries have resulted in small or transient increases in organ donation or even no improvement at all. In the early nineties, Spain started an original integrated approach designed to improve cadaveric organ donation. METHODS In 1989 an official agency,...