In this review, we outline the application and contribution of transgenic technology to establishing the genetic basis of blood pressure regulation and its dysfunction. Apart from a small number of examples where high blood pressure is the result of single gene mutation, essential hypertension is the sum of interactions between multiple environmental and genetic factors. Candidate genes can be ...

s accepted relating to: Transplantation Pharmacology NutritionTransgenics GeneticModels Toxicology BehaviorInfectious Diseases Immunology Physiology ObesityDermatology

“Why don’t you mate mouse X with mouse Y and see what happens?” How many times has one heard that bit of advice? For the beleaguered postdoc assigned to this experiment, the undoubted conclusion will be: Talk is cheap. Actually completing this experiment is expensive, labor-intensive, and time-consuming. The popularity of transgenic cross-breeding studies stems from the wide availability of num...

The susceptibility to multiple sclerosis (MS), a chronic neurological autoimmune disease that primarily targets CNS myelin, has long been associated with HLA class-II genes. Although several other HLA and non-HLA disease predisposing alleles have been identified, alleles of the HLA-DR15 haplotype (DRB1*1501, DRB5*0101, and DQB1*0602) remain the strongest susceptibility factor. Many studies have...

Tocopherols are lipophilic antioxidants that are synthesized exclusively in photosynthetic organisms. In most higher plants, aand g-tocopherol are predominant with their ratio being under spatial and temporal control. While a-tocopherol accumulates predominantly in photosynthetic tissue, seeds are rich in g-tocopherol. To date, little is known about the specific roles of aand g-tocopherol in di...