تعمج تانايبلا . ةيجهنم ةعجارم تناك ةساردلا هذه :هقیرطلا و ةصالخا تاملكلا لامعتساو تانايبلا ةدعاق يف ثحبلا للاخ نم زجالحا " :یتلاا تناك ةصالخا تاملكلا .ثحبلا یف قمعتلا ريياعلما . " ةطبثلما لماوعلا " و "ءاسنلل ةدلاولا لبق ةياعرلا " لوصو" ٬" یف قمعتلا وةساردلا دعب .OR ،AND تناك ةيقطنلما لماوعلا تلااقم تددحو تضفر ةطبارتم ريغ تلااقم ، هفلتخلما تلااقلما تلااقلما رايتخلاا رايعم .تلااقلما لذل اصخلم اها...

conclusions traf6 plays an important role in the onset of colon cancer; therefore, drugs targeting it may have great clinical significance in the treatment of this disease. results the positive expression rate of traf6 in tumor tissues was 66.7%, which was significantly higher than in normal paracancerous tissues (18.5%). the positive expression rate of traf6 was significantly correlated with d...

ةــصلاـخلا : سا وه ةنيجهلا ملعتلا ةمظنأ يدحت نإ تامولعملا رداصم دحأ نم ةعبانلا تامولعملا لامعت رخآ ردصم نع ةمجانلا صئاقنلا ةنزاومل . كلذ و ةدعاو ثحب ةهجو لثمي يزمرلا يكبشلا جزملا نإ ةيزمرلا نيتقيرطلا نيب دضاعتلا نلأ ) ةيرظنلا ( ةيكبشلا و ) ةيبيرجتلا ( لآ لامعتسا نم ةيلاعف رثآأ ادح ىلع امهنم ةدحاو . لا اذه فصي ،يزمر يكبش فنصم ةطساوب ةيفرحلا ةيبرعلا غلابملا ىلع فرعتلل اماظن ثحب ،ةيلاملا غلابملا...

ناآ دقل رهوج ،ةيفخ ةفصب تامولعملا لاسرإ و لاصتلاا عوضوم مدقلا ذنم مامتهلاا و ديعب نمز ذنم عساو لكشب مدختست ةيصنلا قئاثولا تناآ ، صوصنلا يف تامولعملا ءافخلإ ةفلتخم اًقرط مويلا ىتح نمز ذنم دهشن نحن كلذل ) Text Steganography .( لاقملا اذه نإ ط لوانتي ةيبرعلا و ةيسرافلا صوصنلا يف تامولعملا ءافخلإ ةديدج ةقير . و دوآ ينويلا ةفصاوم يف دجوي ) Unicode ( ءايلا فرحل نافلتخم نازمر » ى « ، فاكلا فرحل كلذآو...

BACKGROUND Muscle wasting is observed in the course of many diseases and also during physiological conditions (disuse, ageing). Skeletal muscle mass is largely controlled by the ubiquitin-proteasome system and thus by the ubiquitinating enzymes (E2s and E3s) that target substrates for subsequent degradation. MuRF1 is the only E3 ubiquitin ligase known to target contractile proteins (α-actin, my...

BACKGROUND Muscle-specific RING finger protein-1 (MuRF1) is an E3 ligase that inhibits cardiac hypertrophy. However, how MuRF1 regulates cardiac hypertrophy and function during pressure overload (PO) remains poorly understood. We investigated the role of endogenous MuRF1 in regulating cardiac hypertrophy in response to PO in vivo. METHODS AND RESULTS Transverse aortic constriction (TAC) for 4...

Muscle ring finger-1 (MuRF1) is a muscle-specific E3 ubiquitin ligase that has been implicated in the regulation of cardiac mass through its control of the ubiquitin proteasome system. While it has been suggested that MuRF1 is required for cardiac atrophy, a resting cardiac phenotype has not been reported in mice with a null deletion [knockout (KO)] of MuRF1. Here, we report that MuRF1 KO mice ...

Recent studies implicate the muscle-specific ubiquitin ligase muscle RING finger-1 (MuRF1) in inhibiting pathological cardiomyocyte growth in vivo by inhibiting the transcription factor SRF. These studies led us to hypothesize that MuRF1 similarly inhibits insulin-like growth factor-I (IGF-I)-mediated physiological cardiomyocyte growth. We identified two lines of evidence to support this hypoth...

هديكچ ط ي لاس اه ي خا ي ر پ ي تفرش لباق هظحلام ا ي رد طابترا اب لولس ه ا ي نب ي دا ي لصاح هدش تسا هک ون ي د شخب هار اهراک ي ون ي ن نامرد ي رد ب ي رام ي اه ي بعص جلاعلا م ي .دشاب ا ي ن لولس اه هک رد مامت ناگرا ي مس اه ي دنچ لولس ي روضح ،دنراد اناوت يي سقت ي م و دبت ي ل هب لولس اه يي سب ي را صاصتخا ي ار هتشاد و نچمه ي ن رداق هب اج ي زگ ي ن ...

صخلملا A total of 48 fresh water fishes, belonging to four species of the family Cyprinidae (Capoeta trutta, Chalcalburnus mossulensis, Cyprinion macrostomum and Leuciscus lepidus) were collected from Darbandikhan lake, southwest Sulaimaniya city, Kurdistan region, in the north of Iraq, from March to the end of July 2008. The inspection of gills revealed the infection of these fishes with four ...