glutathione transferase (gst) is a family of multifunctional detoxification enzymes which are mainly cytosolic that detoxify natural and exogenous toxic compounds through conjugation with glutathione tripeptide. its conjugates can be transported to vacuoles or apoplast. these conjugates are generally less toxic than the parent compounds. glutathione transferase is identified and isolated from m...

There are over 24,000 known secondary plant compounds including the alkaloids, non-protein amino acids, cyanogenic glycosides, terpenoids, saponins and flavonoids. Research has concentrated on toxicity and nutritional limitations of plants that result from the presence of secondary compounds. Secondary plant compounds have both anti-nutritional and toxic effects on mammalian herbivores. They al...

BACKGROUND We aimed to assess the content of electronic cigarette (EC) emissions for five groups of potentially toxic compounds that are known to be present in tobacco smoke: nicotine, particles, carbonyls, volatile organic compounds (VOCs), and trace elements by flavor and puffing time. METHODS We used ECs containing a common nicotine strength (1.8%) and the most popular flavors, tobacco and...

The biochemical transformation of mercury, tin, arsenic and bismuth through formation of volatile alkylated species performs a fundamental role in determining the environmental processing of these elements. While the toxicity of inorganic forms of most of these compounds are well documented (e.g., arsenic, mercury) and some of them are of relatively low toxicity (e.g., tin, bismuth), the more l...

In this work we show the effectiveness of 2D structural fingerprints in the prediction of aquatic toxicity of chemical compounds, creating a self-contained system for structure-based aquatic toxicity classification. Using the data from the U.S. Environmental Protection Agency Fat Head Minnow (EPA-FHM) dataset [1] we build a nonlinear RBF SVM [2] classifier that distinguishes acutely toxic compo...

A ll transition metals are highly toxic to life at low levels, but at the same time some, such as manganese, iron, cobalt, nickel, copper, zinc and molybdenum, are essential micronutrients needed to catalyse key enzymatic reactions. To survive, living organisms have had to evolve mechanisms that either remove such metals from their bodies or detoxify and make use of them metabolically. Many of ...

1. The effects of cocaine and its decomposition products were studied on the growth of the young roots of Lupinus albus. 2. The results obtained were compared with similar experiments on animal tissues. 3. It was found that, while cocaine is the most toxic of these compounds studied for animal tissues, it was of comparatively low toxicity in respect to its effect on the growth of roots. On the ...

acanthamoeba keratitis (ak) is a sight-threating infection of the cornea that mostly affects contact lens wearers. until now, ak treatment remains very difficult due to the existence of a highly resistant cyst stage in the life cycle of acanthamoeba which is extremely resistant to most of the available anti-amoebic compounds. moreover, current treatment of ak is usually based in the combination...