STUDY OBJECTIVE To assess concentrations of morphine and its metabolites after patient-controlled analgesia (PCA). DESIGN Pilot pharmacokinetic study of morphine and pharmacokinetic simulation. SETTING Post-anesthesia care room and ward of an academic teaching hospital. PATIENTS 10 ASA physical status I, II, and III postoperative surgical patients. INTERVENTIONS Patients received morphi...

BACKGROUND Lichen planus is a common skin disorder of unknown etiology. Most cases are idiopathic, but substances such as gold, antimalarials, penicillamine, thiazide diuretics, β-blockers, arsenic and nonsteroidal anti-inflammatory drugs have been implicated as trigger factors. CASE PRESENTATION We report the case of a lichenoid eruption in a male drug addict who administered oral heroin (di...

this research was designed to study sexual differences in place conditioning induced by morphine in offspring born of female wistar rats mated with drug-naïve males. mothers were exposed to morphine during the 14th-16th days of gestational. control dams were simply saline-injected. female and male virgin offspring born of morphine-treated or saline-treated mothers were separately housed until b...

Morphine-3- and morphine-6-glucuronide are morphine's major metabolites. As morphine-6-glucuronide produces stronger analgesia than morphine, we investigated the effects of acute and chronic morphine glucuronides on adenylyl cyclase (AC) activity. Using COS-7 cells cotransfected with representatives of the nine cloned AC isozymes, we show that AC-I and V are inhibited by acute morphine and morp...

The photooxidation of thebaine (3) with a sun lamp affords two main products: hydrodibenzofuran 10 (major) and benzofuran 11 (minor). The latter compound becomes predominant if a Hg lamp is used instead of a sun lamp. The formation of 10 proceeds via an endoperoxide intermediate that undergoes oxidation at the nitrogen atom. Protection of the nitrogen either by protonation or quaternization pre...

BACKGROUND Opiates affect blood factors as well as pain and inflammation in a gender-dependent manner. The aim of the present study was to evaluate the effects of morphine on serum glucose, cholesterol, triglycerides, and urea in gonadectomized and inflammation conditions. METHODS Animals were divided as follows: control group, carrageenan and chronic morphine recipients, acute morphine recip...

Clinical studies suggest that essential oil of Eugenia caryophyllata (Clove) buds (EOEC) is efficacious in the treatment of dental pain. In the present study, we investigated the analgesic and local anesthetic effects of EOEC and its possible mechanisms of action in acute corneal pain in rats. EOEC was extracted by hydro-distillation in a Clevenger type apparatus from clove buds. The acute corn...

Mar 1, 2008 . wounds and additional randomized controlled trials with adequate sample sizes and comparison to products noted to decrease odor are. Fifteen (15) studies were identified: seven case reports/series; six descriptive longitudinal studies; and two controlled clinical trials. Metronidazole was used as a . Jun 3, 2014 . Wound odor accumulating from an injury is a problem in wound care t...

We have previously shown that the naturally occurring levo-morphine at a subanalgesic picomolar dose pretreated i.t. induces antianalgesia against levo-morphine-produced antinociception. We now report that the synthetic stereo-enantiomer dextro-morphine, even at an extremely low femtomolar dose, induces antianalgesia against levo-morphine-produced antinociception using the tail-flick (TF) test ...

Leg ulceration is a common and painful complication of sickle cell anemia (SS). Leg ulcers tend to be indolent and intractable and heal slowly over months or years. The pain of these ulcers may be severe, excruciating, penetrating, sharp, and stinging in nature. In most patients, oral or parenteral opioid analgesics may be needed to achieve some pain relief. We wish to report our experience wit...