Objective: The present study was aimed to develop topical gel of Clobetasol propionate with the help of carbopol-934 and Hydroxypropyl methylcellulose K4m as gelling agents. Polymers play major role in various characterization parameters of topical gel such as in vitro release and rheological properties. Methods: Gels were prepared with carbopol-934 and Hydroxypropyl methylcellulose K4m as gell...

OBJECTIVE To evaluate the effectiveness and safety of pentoxyfylline in treatment of perniosis in comparison with prednisolone plus topical clobetasol ointment. METHODS This is an open comparative therapeutic trial conducted in the Department of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq between January and March 2008. Forty patients with perniosis were enrolled in this study, and ...

IMPORTANCE Alopecia areata is an idiopathic cause of hair loss with limited therapeutic repertoire. OBJECTIVE To compare the efficacy and safety of a high- vs low-potency topical corticosteroid in pediatric patients. DESIGN, SETTING, AND PARTICIPANTS This single-center, randomized, blind, 2-arm, parallel-group, superiority trial was carried out over a 24-week period at a tertiary referral a...

Due to the anti-inflammatory and vasodilator effects of topical corticosteroids, they help in treating atopic eczema, psoriasis, chronic hand localized vitiligo, among other dermatological diseases. Clobetasol propionate (CP) is most popular medication used treat plaque psoriasis. It has anti-inflammatory, antimitotic, antipruritic, immunosuppressive characteristics. The USFDA approved CP 0.025...

Background: Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. Corticosteroids are mainstay of treatment but they have many side effects. Therefore, a novel highly necessary.. Objective: To explore effects autoantibodies on keratinocytes and to examine therapeutic potential agent, diacerein. Methods: Cultured HaCaT cells were treated with pur...

Sir, Topical corticosteroids (TCS) are an integral part of dermatological therapeutics. The clinical effects of TCS depend on the structure of the molecule, the vehicle and the skin onto which it is applied.[1] Addition of a fluorine molecule at six and/ or nine positions enhances the potency of TCS. Halobetasol propionate has 6α flouro clobetasol 17-propionate as the active ingredient. Very oc...

INTRODUCTION Several therapeutic options are available for the treatment of vitiligo; among these phototherapy and topical steroids are the most widely documented. A topical formulation of 0.05% clobetasol propionate foam (CPF) has been introduced in the market, but no data are available about the efficacy and tolerability of this new formulation in the treatment of vitiligo. The aim of this st...

Glucocorticoids are used for the treatment of many diseases, such as inflammatory, allergic, autoimmune, and neoplastic diseases. They can be used in the form of topical, oral, inhalable, rectal, and intra-articular agents. Many topical steroid-related iatrogenic Cushing's syndrome cases affecting especially children have been reported in the literature. Topical steroid-related Cushing's syndro...

A 43-year-old woman presented with a widespread morphea, which had its onset three months before. The patient had several plaques of active, pigmented, lilac halo disease on the trunk, arms and thighs. A biopsy confirmed that the patient was suffering from morphea. Therapy with clobetasol propionate ointment 0.05% was introduced, applied twice a day, 5 days a week. After a month, the ointment f...

Lichen nitidus is an uncommon skin condition that is clinically characterized by the presence of pinpoint papules, which are usually asymptomatic, flesh colored, with a flat, shiny surface. The histopathologic feature of it is characteristic. We report a 30-year-old man with typical skin lesions of lichen nitidus confirmed with histopathology, who also had multiple palmar pits. Treatment ...