Aberrant Notch signaling contributes to more than half of all human T-cell leukemias, and accumulating evidence indicates Notch involvement in other human neoplasms. We developed a tetracycline-inducible mouse model (Top-Notch(ic)) to examine the genetic interactions underlying the development of Notch-induced neoplastic disease. Using this model, we show that Notch suppresses p53 in lymphomage...

myocardial fractional flow reserve (ffr) is a new index of the functional significance of intermediate coronary stenoses that is calculated from pressure measurements made during coronary arteriography. the aim of this study was to evaluate the correlation between non-hyperemic coronary pressure dicrotic notch and fractional flow reserve (ffr). a consecutive of 114 patients (73 men and 41 women...

Aberrant Notch signaling contributes to more than half of all human T-cell leukemias, and accumulating evidence indicates Notch involvement in other human neoplasms. We developed a tetracycline-inducible mouse model (Top-Notch) to examine the genetic interactions underlying the development of Notch-induced neoplastic disease. Using this model, we show that Notch suppresses p53 in lymphomagenesi...

PURPOSE The purpose of this study was to compare the size of the entrance of the notch, as measured arthroscopically (2-dimensionally), with the volume of the notch as measured by use of computed tomography (CT) (3-dimensionally). METHODS For 20 cadaveric knees, the dimensions of the notch entrance were measured arthroscopically, and the notch volume was measured by use of CT. The correlation...

In the entire world, there is a widespread recognition that evaluation framework is a key to building stronger and fairer academic institution system. All countries emphasize the evaluation not as end in itself but instead an important tool for achieving improved student outcomes. Teacher evaluation typically has two major purposes. First, it seeks to improve the teacher’s own practice by ident...

the professionals better teachers better schools What to say and what to do when mostly your friends love reading? Are you the one that don't have such hobby? So, it's important for you to start having that hobby. You know, reading is not the force. We're sure that reading will lead you to join in better concept of life. Reading will be a positive activity to do every time. And do you know our ...

Longitudinal results for a randomized-controlled trial (RCT) assessing the impact of increasing preschoolers' attention to print during reading are reported. Four-year-old children (N = 550) in 85 classrooms experienced a 30-week shared reading program implemented by their teachers. Children in experimental classrooms experienced shared-book readings 2 or 4 times per week during which their tea...

This content analysis study, employing a multimodal perspective and critical visual analysis, set out to analyze gender representations in Top Notch series, one of the highly used ELT textbooks in Iran. For this purpose, six images were selected from these series and analyzed in terms of ‘representational’, ‘interactive’ and ‘compositional’ modes of meanings. The result indicated that there are...