In this work, the interaction between a rat cortical thymic epithelial cell (TEC) line (R-TNC.1) with nursing activity and thymocytes as well as BWRT 8 thymocyte hybridoma (TH) cells has been studied. The R-TNC.1 cell line significantly bound thymocytes and TH. Binding was stronger during the first 30 min of cell incubation and was followed by a progressive deadhesion. Among adherent thymocytes...

The extracellular matrix protein tenascin C (TNC) is a large glycoprotein expressed in connective tissues and stem cell niches. TNC over-expression is repeatedly observed in cancer, often at the invasive tumor front, and is associated with poor clinical outcome in several malignancies. The link between TNC expression and poor survival in cancer patients suggests a role for TNC in metastatic pro...

Eight cultivars of tall fescue (Lolium arundinaceum Schreb., S.J. Darbyshire 1⁄4 Festuca arundinacea Schreb.), Barcel, Kenhy, Kentucky-31, Missouri-96, Mozark, Stargrazer, C-1 (an experimental selection), and HiMag, were sampled at 2-h intervals during daylight on four cutting dates. Cultivars varied in concentrations of carbohydrate fractions but accumulation rates were not different. Daily me...

2,4,6-Trinitro-3-methyl-phenol (trinitrocresol, H(+)TNC(-)) was found to inhibit anion and stimulate cation movements across the membranes of both high potassium (HK) and low potassium (LK) sheep red blood cells. The concentration of TNC(-) required to inhibit SO(4) (-) and Cl(-) efflux (10(-5)-10(-3)M) was less than that required to increase Na(+) and K(+) leakage (10(-3)-10(-2)M). Both the in...

Troponin C (TnC)-depleted myofibrils from rabbit skeletal muscle were prepared by consecutive washes of whole myofibrils with EDTA in solutions of low ionic strength, a method which has recently been described for the preparation of TnC (Cox, J. A., Compte, M., and Stein, E. A. (1981) Biochem. J. 195,205-211). Myofibrils treated in this manner exhibit a calcium independent loss of myofibrillar ...

The extracellular matrix (ECM) molecule tenascin C (TNC) is known to be highly expressed under various pathological conditions such as inflammation and cancer. It has been reported that the expression of TNC is correlated with the malignant potential of cancer. In our laboratory, it was found that the peptide derived from the alternative splicing domain A2 in TNC, termed TNIIIA2, has been shown...

C4.4A is a glycolipid-anchored membrane protein expressed in several human malignancies. We recently found that C4.4A expression was associated with poor prognosis of esophageal squamous carcinoma cells (ESCCs), but the underlying mechanism is unknown. To uncover this, we performed PCR array analysis using the HCT116 cell line, a positive control for C4.4A expression and we found that Tenascin-...

OBJECTIVE The thymus is the primary lymphoid organ responsible for T cell development and the establishment of central self-tolerance. Among thymic epithelial cells, thymic nurse cells (TNC) interact closely with immature thymocytes and constitute a special microenvironment for T cell differentiation and selection. In addition, TNC express neuroendocrine self-antigens such as oxytocin and insul...

Control of calcium binding to and dissociation from cardiac troponin C (TnC) is essential to healthy cardiac muscle contraction/relaxation. There are numerous aberrant post-translational modifications and mutations within a plethora of contractile, and even non-contractile, proteins that appear to imbalance this delicate relationship. The direction and extent of the resulting change in calcium ...

Trusted Network Connect (TNC) requires both user authentication and integrity validation of an endpoint before it connects to the internet or accesses some web service. However, as the user authentication and integrity validation are usually done via independent protocols, TNC is vulnerable to the Man-in-the-Middle (MitM) attack. This paper analyzes TNC which uses keys with Subject Key Attestat...