OBJECTIVES Reports in autism spectrum disorders (ASD) of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on low frequency repetitive Transcranial Magnetic Stimulation (rTMS) will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and will be a...

A mixture oftrimethylchlorosilane (TMS-Cl), lithium and tetrahydrofuran (THF) reacts with imines to produce disilyl compound by addition of two trimethylsilyl (TMS) groups to the double bond of the imine. On hydrolysis the TMS on nitrogen is substituted by hydrogen and yields ? -silylamine. In the presence of acetyl chloride (CH COC1), benzene and pyridine, the ?-silyamine produces the corresp...

a mixture oftrimethylchlorosilane (tms-cl), lithium and tetrahydrofuran (thf) reacts with imines to produce disilyl compound by addition of two trimethylsilyl (tms) groups to the double bond of the imine. on hydrolysis the tms on nitrogen is substituted by hydrogen and yields ? -silylamine. in the presence of acetyl chloride (ch coc1), benzene and pyridine, the ?-silyamine produces the correspo...

Transcranial magnetic stimulation (TMS) is a unique method in neuroscience used to stimulate focal regions of the human brain. As TMS gains popularity in experimental and clinical domains, techniques for controlling the extent of brain stimulation are becoming increasingly important. At present, TMS intensity is typically calibrated to the excitability of the human motor cortex, a measure refer...

BACKGROUND Pairing peripheral electrical stimulation (ES) and transcranial magnetic stimulation (TMS) increases corticospinal excitability when applied with a specific temporal pattern. When the two stimulation techniques are applied separately, motor imagery (MI)-related oscillatory modulation amplifies both ES-related cortical effects-sensorimotor event-related desynchronization (ERD), and TM...

The spatial extent of transcranial magnetic stimulation (TMS) is of paramount interest for all studies employing this method. It is generally assumed that the induced electric field is the crucial parameter to determine which cortical regions are excited. While it is difficult to directly measure the electric field, one usually relies on computational models to estimate the electric field distr...

Transcranial magnetic stimulation (TMS) has been applied to a growing number of psychiatric disorders as a noninvasive probe to study the underlying neurobiologic processes involved in psychiatric disorders and as a putative treatment. Transcranial magnetic stimulation is unparalleled in its ability to test the hypotheses generated by functional neuroimaging studies by modulating activity in se...

Phosphene sensation is commonly used to measure cortical excitability during transcranial magnetic stimulation (TMS) of the occipital cortex. However, some individuals lack this perception, and the reason for it is still unknown. In this work, we used functional magnetic resonance imaging (fMRI) to detect brain activation during local TMS of the occipital cortex in twelve healthy subjects. We f...

Transactional Memory (TM) is a promising abstraction as it hides all synchronization complexities from the programmers of concurrent applications. More particularly the TM paradigm operated a complexity shift from the application programming to the TM programming. Therefore, expert programmers have now started to look for the ideal TM that will bring, once-for-all, performance to all concurrent...

For nearly two decades now, transcranial magnetic stimulation (TMS) has been available as a noninvasive clinical tool to treat patients suffering from major depression. In this period, a bulk of animal and human studies examined TMS parameters to improve clinical outcome. However, the neurobiological mechanisms underlying mood changes remain an important focus of research. In addition to having...