One titrimetric and two spectrophotometric methods which are simple, sensitive, and economic are described for the determination of sumatriptan succinate (STS) in bulk drug and in tablet dosage form using N-bromosuccinimide (NBS) as a brominating agent. In titrimetry, aqueous solution of STS is treated with a measured excess of NBS in acetic acid medium, and after the bromination of STS is judg...

Three indirect methods for the quality control of olanzapine (OLP) in commercial formulations based on titrimetric and spectrophotometric techniques are described using N-bromosuccinimide (NBS) and two dyes, namely amaranth and janus green B as reagents. In titrimetry, a measured excess of NBS is added to an acidified solution of OLP and the unreacted NBS is determined iodometrically. Spectroph...

A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between EDTA and magnesium ion. The method was proven to be valid, equivalent and useful as an alternati...

Titrimetric estimation of calcium with disodium ethylene diamine tetra-acetate (E.D.T.A., sodium edetate), as performed on serum (Baron and Bell, 1957), cannot be applied directly to most other biological specimens because of their high concentration of phosphate. A high ratio of phosphate to calcium in the material titrated causes a drawnout and inaccurate endpoint. A rapid procedure for calci...

The present paper deals with the secondary metabolite contents such as saponin, total tannin and anthraquinone during three different developmental stages vegetative, flowering fruiting in Alhagi maurorum from Rajasthan desert. study of this plant is needed due to its higher medicinal values. aim quantitative estimation selected metabolites. amounts were evaluated by HPLC, titrimetric GC/MS/MS ...

Dole’s titrimetric method for determination of the free fatty acide of plasma has been modified to improve ita specificity. The fatty acid solution which is to be titrated ie first washed with 0.06 per cent H,SO, and thus freed of lactic acid and of an acetone-insoluble material which interferes. With this change, the Dole procedure yields results which agree well with those of Gordon’s me...

Powell (1953) introduced a method for the estimation of serum calcium using the EEL flame photometer, and claimed that it gave results in good agreement with a standard titrimetric procedure. In this laboratory, both these methods were found to give low results when tested against standard sera, prepared by adding known amounts of calcium to serum completely decalcified by treatment with a cati...