Gelatin-resorcin-formalin (GRF) glue was developed by Braunwald and Tatooles in 1964. Initially, it was mainly used as a hemostatic agent by gastrointestinal surgeons and urologists. In 1977, Bachet et al. used GRF glue as an adhesive and hemostatic material for aortic surgery and reported that it was very useful. The use of GRF glue dramatically improved the outcomes of surgery for Stanford ty...

The purpose of this study was to demonstrate the feasibility of using a fibrin glue polymer to produce injectable tissue-engineered cartilage and to determine the optimal fibrinogen and chondrocyte concentrations required to produce solid, homogeneous cartilage. The most favorable fibrinogen concentration was determined by measuring the rate of degradation of fibrin glue using varying concentra...

OBJECTIVES In this study, we determined whether fibrin glue improves cell transplant retention and survival, reduces infarct expansion, and induces neovasculature formation. BACKGROUND Current efforts in restoring the myocardium after myocardial infarction (MI) include the delivery of viable cells to replace necrotic cardiomyocytes. Cellular transplantation techniques are, however, limited by...

Recently, we have described a simple protocol to obtain an enriched culture of adult stem cells organized in neurospheres from two post-natal tissues: skin and adipose tissue. Due to their possible application in neuronal tissue regeneration, here we tested two kinds of scaffold well known in tissue engineering application: hyaluronan based membranes and fibrin-glue meshes. Neurospheres from sk...

BACKGROUND In surgical and endoscopic procedures, tissue adhesives are commonly used as reinforcement of sutures or as bonding and hemostatic agents. Fibrin glues do not guarantee adequate properties for many clinical applications; on the contrary, cyanoacrylate glues guarantee high bonding strength between biologic tissues. The aim of this study was to provide evidence regarding adhesive and s...

BACKGROUND The absence of incorporation between endoprosthesis (EP) and the arterial wall may lead to device migration and endoleaks around the stent graft. Alternatives have been tested aiming to improve this incorporation. Fibrin glue is used in many operating procedures promoting adhesion and tissue regeneration; however, its use to improve EP incorporation by arteries is unknown. OBJECTIV...

Alternative methods of wound closure after formal circumcision have been studied to decrease the repair time and complications, and to improve cosmesis. This was a prospective non-comparative preliminary clinical study involving 15 patients where Cyanoacrylate glue was used as a tissue adhesive for wound closure after formal circumcision. It was found that the repair time was short, complicatio...

BACKGROUND AND OBJECTIVES The purposes of this study were to demonstrate that laser soldering is safe and effective for tissue bonding in dural reconstruction and to compare this new reconstruction technique to an established one. STUDY DESIGN A temperature-controlled fiberoptic CO(2) laser system or fibrin glue were used for in vitro dural defect reconstruction in two groups of pigs. The CO(...